Separating Metabolite Contribution from Multiple CEST Pools at 7T

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Physics (MSc)

Plugge, Jaimy (2020)

Separating Metabolite Contribution from Multiple CEST Pools at 7T

Master thesis | Physics (MSc)

In this thesis, the potential of Chemical Exchange Saturation Transfer to image brain metabolites is presented. The Bloch-McConnell equations are simulated and the optimal parameters are found to be 3.5uT, tsat = 1s for glutamate and 3uT, tsat = 1.5s for creatine. Furthermore, multiple quantification methods, including MTR asymmetry, Lorentzian fits and spinlock fits are evaluated for quantifying CEST signal from glutamate and creatine. The quantification methods are tested on the Bloch-McConnell simulations, 2-pool phantoms, 3-pool phantoms and in vivo.

Bloch-McConnell equations