De rol van CA en cortisol in de ontwikkeling van depressieklachten na de eerste lockdown tijdens de COVID-19 pandemie

Background: It is unclear if COVID-19 measurements affect adolescent with a history of Childhood Aversity (CA) more than other adolescents. It is important to find out, because CA already predicts more risk for psychological problems such as depression. CA can also have an impact on the stress hormone cortisol, which can lead to less or more depressive symptoms. Research is needed to find out if CA and cortisol can be of risk for developing depression after lockdown due to COVID-19 or if adolescents will be resilient to these kinds of stressors. Method: The sample consisted of 89 adolescents with a history of CA, recruited through an earlier study named Resilience after Individual Stress Exposure (RAISE). The adolescents filled in two questionnaires: Childhood Trauma Questionnaire (CTQ) and Mood and feelings questionnaire (MFQ). They also performed an fMRI stress task (MIST) where prior to this test blood was contained for measurement of cortisol. After the first lockdown of COVID...Show moreBackground: It is unclear if COVID-19 measurements affect adolescent with a history of Childhood Aversity (CA) more than other adolescents. It is important to find out, because CA already predicts more risk for psychological problems such as depression. CA can also have an impact on the stress hormone cortisol, which can lead to less or more depressive symptoms. Research is needed to find out if CA and cortisol can be of risk for developing depression after lockdown due to COVID-19 or if adolescents will be resilient to these kinds of stressors. Method: The sample consisted of 89 adolescents with a history of CA, recruited through an earlier study named Resilience after Individual Stress Exposure (RAISE). The adolescents filled in two questionnaires: Childhood Trauma Questionnaire (CTQ) and Mood and feelings questionnaire (MFQ). They also performed an fMRI stress task (MIST) where prior to this test blood was contained for measurement of cortisol. After the first lockdown of COVID-19 the MFQ was filled in again. Results: The results stated that after the lockdown the depression symptoms were increased (Z = 4,122, p < .001). But threat and deprivation (both CA) were not predictors of cortisol (threat: b = -.214, t (87) = -200, p = .842, deprivation: b = .316, t (87) = .2523, p = .801). Cortisol did not have mediation effect between threat/deprivation and changes in depression symptoms (threat: 95% CI [-.017,.026], deprivation: 95% CI [-.037,.031]). And lastly only threat was a predictor for changes in depression symptoms (b = .255, t (87) = 2.3863, p = .019). Discussion: This research has proved that there is an increase in depressive symptoms after the first lockdown in April of the year 2020. Secondly, history of threat and deprivation are not predictors of cortisollevels in the adolescence. Third, cortisol did not play a mediation role between CA (threat/deprivation) and depressive symptoms. Lastly, threat predicts depressive symptoms after the lockdown. In future similar situations, to prevent development of (more) depressive symptoms that may lead to depression disorder, extra support for adolescents, especially with history of threat, is needed.Show less

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De rol van CA en cortisol in de ontwikkeling van depressieklachten na de eerste lockdown tijdens de COVID-19 pandemie