Amygdala Volumes in Conduct Disordered  Juvenile Offenders with Callous-Unemotional Traits

Conduct Disorder (CD) is a common psychiatric disorder of childhood and adolescence characterized by severe aggressive and antisocial behaviors that often result in impaired social, academic, or occupational functioning. The subtype CD with callous-unemotional (CU) traits has been suggested to be part of the developmentary trajectory of psychopathy, with both being linked to amygdalar volume deficits. Research into the neurodevelopmental perspective of CD/CU+ has been inconsistent due to methodological, demographic and cultural factors. Therefore, the current study examined amygdala morphology in two matched juvenile groups: CD offenders (N = 51) and healthy control subjects (HC; N = 36). In an additional set of analyses, the CD group was divided in two subgroups: CD with CU traits (CD/CU+; N = 26), CD without CU traits (CD/CU-; N = 25), and compared to HC participants. Additionally, the influence of CU traits on brain morphology was assessed in a dimensional manner across all...Show moreConduct Disorder (CD) is a common psychiatric disorder of childhood and adolescence characterized by severe aggressive and antisocial behaviors that often result in impaired social, academic, or occupational functioning. The subtype CD with callous-unemotional (CU) traits has been suggested to be part of the developmentary trajectory of psychopathy, with both being linked to amygdalar volume deficits. Research into the neurodevelopmental perspective of CD/CU+ has been inconsistent due to methodological, demographic and cultural factors. Therefore, the current study examined amygdala morphology in two matched juvenile groups: CD offenders (N = 51) and healthy control subjects (HC; N = 36). In an additional set of analyses, the CD group was divided in two subgroups: CD with CU traits (CD/CU+; N = 26), CD without CU traits (CD/CU-; N = 25), and compared to HC participants. Additionally, the influence of CU traits on brain morphology was assessed in a dimensional manner across all participants (N = 87). Analyses revealed significant lower left amygdalar volumes in all CD youth compared to HC youth, while no significant differences emerged in the right amygdalar volumes. Furthermore, no significant differences in amygdalar volumes emerged between CD/CU- vs. CD/CU+ vs. HC youths. Moreover, the severity of CU traits did not relate to brain morphology in a dimensional manner across all participants. The current findings reflect the complexity and inconsistency of research into the relationship between brain morphology and CD diagnosis, and add to the research into the neurodevelopmental perspective of CD/CU+Show less

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Amygdala Volumes in Conduct Disordered Juvenile Offenders with Callous-Unemotional Traits