Leiden University Student Repository

Kuiper, Sterre (2025)

Switching Between the Default Mode Network and the Central Executive Network: Gender Disparities and the Role of Brooding Rumination

Master thesis | Psychology (MSc)

Depression is a leading cause of burden worldwide, disproportionately affecting women. Brooding rumination is a symptom and a risk factor for depression. The default mode network (DMN) is active during brooding rumination. Inadequate suppression of this network obstructs activation of the central executive network (CEN), essential for performing cognitively demanding tasks. While previous research linked DMN suppression to depression, this has not been investigated in a healthy population. This study examined potential gender differences in the time required to switch from the DMN to the CEN in a healthy sample. Additionally, it investigated whether switching time was positively related to brooding rumination and whether this relationship differed between genders. Lastly, it explored whether functional connectivity (FC) between the DMN and the subgenual anterior cingulate cortex (sgACC) was related to brooding rumination. Results indicated a faster DMN-CEN switch in men compared to...Show moreDepression is a leading cause of burden worldwide, disproportionately affecting women. Brooding rumination is a symptom and a risk factor for depression. The default mode network (DMN) is active during brooding rumination. Inadequate suppression of this network obstructs activation of the central executive network (CEN), essential for performing cognitively demanding tasks. While previous research linked DMN suppression to depression, this has not been investigated in a healthy population. This study examined potential gender differences in the time required to switch from the DMN to the CEN in a healthy sample. Additionally, it investigated whether switching time was positively related to brooding rumination and whether this relationship differed between genders. Lastly, it explored whether functional connectivity (FC) between the DMN and the subgenual anterior cingulate cortex (sgACC) was related to brooding rumination. Results indicated a faster DMN-CEN switch in men compared to women. No relationship was found between switching time and brooding rumination in either men or women. Lastly, brooding rumination showed no relationship with sgACC-DMN FC. This study proposes a slower DMN-CEN switch as a possible neural mechanism for higher rates of depression and relapse proneness in women compared to men. Moreover, it suggests that DMN suppression may not underlie brooding rumination as a risk factor for MDD. Researchers developing preventive measures for depression aimed at reducing brooding rumination may consider targeting other neural mechanisms than DMN suppression. Future research should explore these alternative neural mechanisms to support the development of preventive measures for the onset and relapse of depression.Show less

Major Depressive Disorder, Brooding Rumination, Default Mode Network, Central Executive Network

Author

Kuiper, Sterre

Faculty

Faculty of Social & Behavioural Sciences

Specialisation

Clinical Psychology

Supervisors

Rover, M. de

ECTS Credits

20

Language

en