Exploring the possible mediation of stress in the relationship between quality of life and adverse childhood events in adolescents with SUD

This study has investigated the (possibly) mediating role of stress in the relationship between adverse childhood experiences (ACEs) and quality of life (QoL) in adolescents with substance use disorder (SUD), whilst correcting for the severity of the addiction. Adolescents are vulnerable to developing SUD and as substance misuse has a neurodegenerative effect, it is important to understand the mechanics behind SUD in adolescents. This current study consisted of 334 adolescents with SUD, with the age ranging from 16 to 23 years old. Cannabis was the primary substance for which participants entered treatment (63.5%), followed by alcohol (17.7%) and cocaine (11.1%). The WHODAS-2.0 was used to measure Qo. To measure self-reported stress the DASS-21 was used, whereas hair cortisol concentration (HCC) was used to measure chronic stress. The YIT-Q was used to measure the ACEs and finally, the MATE-Y was used to measure the SUD severity. HCC is a proposed biomarker for chronic stress. As it...Show moreThis study has investigated the (possibly) mediating role of stress in the relationship between adverse childhood experiences (ACEs) and quality of life (QoL) in adolescents with substance use disorder (SUD), whilst correcting for the severity of the addiction. Adolescents are vulnerable to developing SUD and as substance misuse has a neurodegenerative effect, it is important to understand the mechanics behind SUD in adolescents. This current study consisted of 334 adolescents with SUD, with the age ranging from 16 to 23 years old. Cannabis was the primary substance for which participants entered treatment (63.5%), followed by alcohol (17.7%) and cocaine (11.1%). The WHODAS-2.0 was used to measure Qo. To measure self-reported stress the DASS-21 was used, whereas hair cortisol concentration (HCC) was used to measure chronic stress. The YIT-Q was used to measure the ACEs and finally, the MATE-Y was used to measure the SUD severity. HCC is a proposed biomarker for chronic stress. As it is relatively new, HCC has not yet been investigated for adolescents with SUD. Two mediations were investigated, one with HCC as variable for stress, and one with self-reported stress. Study findings showed that the relationship between ACEs and QoL was fully mediated by self-reported stress, whereas no mediation was found for HCC. This indicates a difference in HCC and self-reports as a measure of stress and highlights the importance for continued research into HCC as biomarker for chronic stress. A recommendation for future research is to further investigate the usability of HCC as a biomarker for chronic stress, for example by continuing investigating HCC in adolescents with SUD, as current study was the first to do so. Additionally, it is recommended to repeat the mediation analysis in a broader population to investigate whether HCC does have a mediating role in other populations.Show less

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Exploring the possible mediation of stress in the relationship between quality of life and adverse childhood events in adolescents with SUD