Major Depressive Disorder Impairs Steadiness but Not Other Manual Motor Functions

Major depressive disorder (depression) is a prevalent mental health condition characterized by mood disturbance, but it can also impact motor functioning. Impairments in gross motor skills, like slower backward walking and compromised balance, are well-documented, but the effects on manual motor skills, important for precise tasks like buttoning clothes, are less studied. Therefore, this study examined whether individuals with depression perform worse on manual motor tasks compared to healthy controls (HC), and if mood changes over 4 months correlate with motor performance changes in those with depression. Manual motor functioning was measured in 20 people with depression and 22 HC (mean age = 31 years) via five tasks: steadiness, line tracking, aiming, tapping, and pin insertion. Depressive symptoms were assessed with the Hamilton Depression Rating Scale (HAMD) and Patient Health Questionnaire (PHQ). Quality of life was evaluated using the World Health Organization Quality of Life ...Show moreMajor depressive disorder (depression) is a prevalent mental health condition characterized by mood disturbance, but it can also impact motor functioning. Impairments in gross motor skills, like slower backward walking and compromised balance, are well-documented, but the effects on manual motor skills, important for precise tasks like buttoning clothes, are less studied. Therefore, this study examined whether individuals with depression perform worse on manual motor tasks compared to healthy controls (HC), and if mood changes over 4 months correlate with motor performance changes in those with depression. Manual motor functioning was measured in 20 people with depression and 22 HC (mean age = 31 years) via five tasks: steadiness, line tracking, aiming, tapping, and pin insertion. Depressive symptoms were assessed with the Hamilton Depression Rating Scale (HAMD) and Patient Health Questionnaire (PHQ). Quality of life was evaluated using the World Health Organization Quality of Life (WHOQOL) questionnaire. ANCOVAs analyzed group differences, and linear regressions examined longitudinal associations using both frequentist and Bayesian approaches. Results showed that, compared to HC, participants with depression had longer error durations for line tracking, longer total durations for aiming, and fewer hits for tapping, Fs > = 4.946, ps < 0.032, ηp2s > 0.113, BFs10 > 0.050 (uncorrected). No group differences were found for other measures. Longitudinally, within the depressed group, improvements in HAMD-17 and HAMD-24 scores were significantly associated with fewer errors and shorter error durations in steadiness, βs > 0.739, ps < 0.043 BFs10 > 1.000 (uncorrected). Exploratory analyses provided anecdotal evidence for the associations between physical health improvements and decreased error duration in steadiness, β = -0.542, p = 0.044, BF10 = 1.933, and psychological health improvements and decreased task duration in line tracking, β = -0.623, p = 0.025, BF10 = 1.494. The results suggest that depression may specifically affect steadiness. Additionally, physical and psychological health factors were linked to overall manual motor functioning. Limitations include the small sample size and focus on a single subtype of depression. Some authors suggest that current diagnostic methods overlook manual motor functioning in depression, but evidence remains insufficient for clinical application. Larger studies with various depression subtypes and chronicity levels, incorporating both behavioral and fMRI measures, are needed to further investigate the theoretical foundations of manual motor impairments in depression.Show less

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Major Depressive Disorder Impairs Steadiness but Not Other Manual Motor Functions