Characterizing iron-oxide nanoparticles in the human brain

Persistent URL of this record https://hdl.handle.net/1887/72503

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Physics (MSc)

Boers, Laurens (2018)

Characterizing iron-oxide nanoparticles in the human brain

Master thesis | Physics (MSc)

In this study, we employed several methods to characterize iron-oxide nanoparticles using SQUID magnetometry and MRI. With SQUID magnetometry, we measured the Isothermal Remanent Magnetization of C. Elegans and two human brain samples. We obtained the iron concentration from the fit. We were able to detect changes in iron concentration due to mutations in C. Elegans. For the MRI measurements, we used Quantitative Susceptibility Mapping and an Off-Resonance Saturation method for brain phantoms. These phantoms consist of different concentrations of magnetite or ferritin dissolved in an agarose gel and mimics the human brain. With QSM we observed a comparable slope of the susceptibility/µg iron/ml. For the ORS method, a good agreement is found between the obtained iron concentration and the pre-determined iron concentration in the sample.

Quantitative Susceptibility Mapping

Isothermal Remanent Magnetization