Met de vergrijzing van de bevolking groeit ook het belang van een vroege en nauwkeurige diagnose van neurodegeneratieve aandoeningen zoals de ziekte van Alzheimer (AD). Dit onderzoek richt zich...Show moreMet de vergrijzing van de bevolking groeit ook het belang van een vroege en nauwkeurige diagnose van neurodegeneratieve aandoeningen zoals de ziekte van Alzheimer (AD). Dit onderzoek richt zich specifiek op het verkennen van de verschillen tussen twee vormen van AD, namelijk Early-Onset Alzheimer's Disease (EOAD) en Late-Onset Alzheimer's Disease (LOAD), met als doel het verbeteren van classificatiemodellen. We hebben vier classificatiemodellen ontworpen, elk gericht op specifieke hersengebieden die mogelijk atrofie vertonen, met Model 1 en 2 gericht op respectievelijk LOAD en EOAD, Model 3 als een gecombineerd model en Model 4 dat de algehele hersenatrofie omvat. Deze modellen zijn geanalyseerd aan de hand van Area Under the Curve (AUC) en zijn ontwikkeld met behulp van logistische regressie en LASSO om de meest relevante variabelen te selecteren. Onze bevindingen suggereren dat EOAD en LOAD verschillende neuropathologische patronen vertonen, waarbij EOAD mogelijk wordt gekenmerkt door specifiekere neuropathogenese patronen, terwijl LOAD meer uniforme hersenveranderingen vertoont. Model 3, dat specifieke hersengebieden combineerde, presteerde het beste bij het classificeren van beide groepen, terwijl Model 4, dat alle hersengebieden omvatte, een lagere classificatie-accuratesse vertoonde voor EOAD. Deze resultaten benadrukken dat AD patiënten geen homogene groep zijn en benadrukken het belang van gedifferentieerde diagnostische benaderingen om rekening te houden met de heterogeniteit binnen deze aandoening.Show less
Prosocial behavior, defined as any action taken to benefit another, has maintained persistent interest in regarding its intricate relationship with loneliness and apathy. Loneliness, conceptualized...Show moreProsocial behavior, defined as any action taken to benefit another, has maintained persistent interest in regarding its intricate relationship with loneliness and apathy. Loneliness, conceptualized as a subjective feeling of social isolation is often found comorbid with apathy; one’s reduced motivation to put in effort for others’ benefit relative to one’s own benefit. Although all three variables demonstrate a relationship to one another, research remains scarce regarding their shared impact. However, findings show a positive influence of prosocial behaviors on social connections, consequently decreasing experiences of isolation as well as apathy. This investigation aims to uncover the potential mediating effect of prosocial behavior on the bidirectional relationship of loneliness and apathy. To fill the gap in the literature, assessing both models helps highlight intervention approaches aiming to effectively break the cycle – ultimately improving well-being. Higher levels of loneliness are expected to indicate higher levels of apathy, whereas prosocial behaviors may mediate and limit the negative affect. Ultimately, it is also expected higher levels of apathy lead to higher levels of loneliness, with prosocial behavior possibly mitigating this negative affect. 287 participants underwent a behavioral task assessing their prosocial tendencies, as well as questionnaires measuring their level of loneliness and apathy. Both mediation analyses revealed a significant total effect between the variables. This was indicative of a negligible mediating role of prosocial acts. These results underline the specific gaps left for future research, ranging from exploring the nuanced relationships and contextual factors involved affecting the constructs over time.Show less
Research suggests a prominent relationship between self-esteem and social evaluation, such that individuals with low self-esteem may show biased perceptions of social evaluation. This study...Show moreResearch suggests a prominent relationship between self-esteem and social evaluation, such that individuals with low self-esteem may show biased perceptions of social evaluation. This study examines interactions between self-esteem, attachment styles, and neural sensitivity to social feedback using electroencephalography (EEG). The focus was on the Feedback-Related Negativity (FRN) component, indicative of neural sensitivity to expectancy violations in social feedback. It was hypothesized that low self-esteem would predict greater FRN during the SELF-Profile task, with insecure attachment styles adding to the variance of this relationship. Individuals with insecure attachment styles were also predicted to underestimate proportions of acceptance feedback received during the task, with low self-esteem and an insecure attachment predicting a lower proportion of expected acceptance feedback. Eighty adolescents aged 12-to-18 years (60 females, 20 males) participated in this study. Participants completed the SELF-Profile task, involving receiving probabilistic feedback from peers on social-media-like profiles, mimicking real-word scenarios of social feedback and potential uncertainties around these interactions. Participants indicated their perception of the interaction, reporting percentages of perceived social acceptance from peers. EEG recordings were conducted throughout this task. Results demonstrated that participants with low self-esteem exhibited heightened FRN amplitudes in response to positive incongruent feedback, suggesting increased sensitivity to unexpected positive social feedback. Moreover, individuals with insecure attachment styles show trends of amplified neural reactivity to social feedback which was visible in FRN outputs. Regression analyses additionally found significant correlations between self-esteem, attachment style and overall expectation of social feedback (positive and negative), with self-esteem explaining most of the variance. These findings elucidate neural mechanisms underlying feedback processing in relation to self-esteem and attachment, suggesting that low self-esteem and insecure attachment styles influence our social feedback sensitivity and expectation. Results provide insights for clinical practice suggesting the importance of improving self-esteem when working on client difficulties in social settings through positive feedback reinforcement.Show less
Steun die vanuit ouders wordt ontvangen blijkt uit onderzoek negatief samen te hangen met depressie symptomen in adolescenten. Uit onderzoek blijkt daarnaast dat adolescenten die lage steun vanuit...Show moreSteun die vanuit ouders wordt ontvangen blijkt uit onderzoek negatief samen te hangen met depressie symptomen in adolescenten. Uit onderzoek blijkt daarnaast dat adolescenten die lage steun vanuit ouders, maar hoge steun vanuit vrienden ontvangen, meer depressie symptomen laten zien dan adolescenten die vanuit beide groepen lage steun ontvangen. In dit cross-sectionele onderzoek is gekeken of dit effect ook te vinden is in een gedeeltelijk klinische steekproef. Gezonde (N = 80) en depressieve adolescenten (N = 35) voerden een gesprek met hun ouders over een emotionele gebeurtenis. Hierna werd de steun vanuit de ouders tijdens het gesprek beoordeeld door de adolescenten. Deze steun vanuit ouders was negatief gecorreleerd met depressie symptomen bij de adolescenten. Steun vanuit vrienden bleek deze negatieve relatie niet significant te beïnvloeden. Er zal meer onderzoek gedaan moeten worden in welke context steun vanuit vrienden wel of niet deze relatie tussen steun vanuit ouders en depressie beïnvloedt.Show less
Climate change is a serious threat to the future ecological environment, and household behaviors contribute significantly to greenhouse gas emissions. Engaging young people in sustainable household...Show moreClimate change is a serious threat to the future ecological environment, and household behaviors contribute significantly to greenhouse gas emissions. Engaging young people in sustainable household behaviors is crucial to reduce their carbon footprints. Therefore, this study aimed to investigate whether young adults’ perceived need for autonomy, relatedness, and competence vary across different living situations (Deci & Ryan, 2000) and if these needs, in turn, promote their motivation to perform pro-environmental behavior (PEB). The hypothesis was that students living in peer co-residentials experience higher levels of these needs, leading to increased PEB. Methods: This observational and cross-sectional study was part of the Horizons research project. The participants included students (N = 214), aged 16 to 26. The Needs-satisfaction Scale (Sheldon et al., 2001) was used to measure perceived autonomy, relatedness and competence for PEB. A modified version of the Behavior-based Environmental Attitude Scale for adolescents (Kaiser et al., 2007) was used to assess PEB. Living situations were categorized as peer co-residentials, parental homes, and other households. One-way ANOVAs were performed to analyse the levels of the needs across the household types. A between-subject ANCOVA was performed to analyse the main effects of household, autonomy, relatedness and competence on PEB, including interaction effects. Results: No significant differences were found in the levels of perceived needs across the household types, p >. 05. Similarly, no main effects on PEB were identified, p >. 05. However, a significant interaction effect between perceived competence and household type on PEB was observed, F(3, 204) = 4.55, p < .001. Regression analysis revealed an interaction between perceived competence and PEB within in parental households, F(1, 74) = 4.39, p = .04, with competence having a significant and positive effect on PEB, b = .77, t(75) = 2.09, p < .001. Conclusion: Within parental homes, students who perceived more competence while performing PEB were more inclined to engage in PEB. Except for this effect, the findings revealed no significant differences in perceived needs or levels of PEB across household types. This study highlights that young adults’ perceived competence in parental homes plays a role in their environmental engagement. Future research may explore how parent-child relationships continue to shape young adult’s perceived needs after they move out. Understanding these dynamics can inform programs aimed at engaging young adults’ pro-environmental behavior, leading to reduced household carbon footprints over time.Show less
The global prevalence of Alzheimer’s disease is expected to rise from 50 to 152 million cases by 2050 due to the limited availability of therapeutic and preventive strategies and ageing populations...Show moreThe global prevalence of Alzheimer’s disease is expected to rise from 50 to 152 million cases by 2050 due to the limited availability of therapeutic and preventive strategies and ageing populations. Although digital tools can address the growing gap between healthcare supply and demand, their implementation is difficult, and personal factors can influence individuals’ intention to use such tools. Thus, this study explores the relationship between various personal factors, as self-reported by healthy individuals (N = 507) who are part of a brain research registry, and their intention to use and promote using digital tools in the context of brain health and dementia. According to the hypothesis formulated for the research, higher financial scarcity, lower educational attainment, and lower employment status predict lower intention to use and promote digital tools for brain health. The study examined four distinct digital tools: (1) MijnBreincoach (a prevention tool), (2) cCog (a diagnostic tool), (3) ADappt (a patient- orchestrated care tool), and Neurokeys (a prediction tool). It was found that Neurokeys exhibited the highest score for intention to use but the lowest score for intention to promote. In addition, medium and high educational attainment predicted higher behavioral intention to use MijnBreincoach, while the most beneficial (i.e., most secure, stable, and safe) employment status predicted higher intention to promote MijnBreincoach and cCog. In conclusion, it is important to recognize differences in intention to use and promote different types of digital tools across potential users and the influence of personal characteristics on the intention to use and promote digital tools for brain health. During the development of a digital tool, it is recommended to consider which target audience would derive the greatest benefit from it and tailor it accordingly.Show less
This 3-wave study aims to examine the relationship between cognitive empathy (awareness and understanding of another’s emotion), affective empathy (experience of emotions consistent with those of...Show moreThis 3-wave study aims to examine the relationship between cognitive empathy (awareness and understanding of another’s emotion), affective empathy (experience of emotions consistent with those of the observed person), and self-perception of close friendships (one’s perception of the ability to form and maintain close friendships), both directly and indirectly through prosocial behavior (voluntary behavior intended to benefit another person) from late childhood to early adolescence. Participants were 127 adolescents aged between 10 and 14 years old who reported on their empathy, prosocial behavior, and self-perception of close friendships in three consecutive years, respectively. Simple mediation analyses revealed that cognitive and affective empathy did not have a significant positive effect on adolescents’ self-perception of close friendships two years later. Considering these findings, prosocial behavior was not found to be a mediator between adolescents’ cognitive or affective empathy and their self-perception of close friendships from late childhood to early adolescence. Moreover, cognitive and affective empathy did not significantly predict prosocial behavior one year later, whereas prosocial behavior did significantly predict the self-perception of adolescents’ close friendships one year later. These results underline the significance of developing tailored intervention programs targeting prosocial behavior to foster adolescents’ self-perception as close friends, a competence that is crucial during this developmental period considering the greater influence of peers.Show less
Gezonder eten: een doel dat velen van ons nastreven, maar vaak lukt het niet dit gedrag vol te houden. Op dat moment vindt er een terugval plaats, ook wel een setback genoemd. Na het ervaren van...Show moreGezonder eten: een doel dat velen van ons nastreven, maar vaak lukt het niet dit gedrag vol te houden. Op dat moment vindt er een terugval plaats, ook wel een setback genoemd. Na het ervaren van een setback wordt het moeilijker een gedragsdoel vol te houden. Deze studie onderzoekt waarom dit moeilijk wordt door de relatie tussen de ervaren setbacks tijdens het volgen van een dieet en maintenance self-efficacy te analyseren, met subjectief succes als mogelijke mediator. Met een online vragenlijst (N= 74) zijn de ervaren setbacks, maintenance self-efficacy en subjectief succes uitgevraagd. De vragenlijst had een cross-sectioneel, between-subjects design. De antwoorden op de vragenlijst zijn geanalyseerd met lineaire regressieanalyses en met een mediatie analyse. De resultaten lieten een significante negatieve relatie zien tussen de ervaren setbacks en maintenance self-efficacy. De relatie tussen de ervaren setbacks en subjectief succes was significant negatief, maar de relatie tussen subjectief succes en maintenance self-efficacy was niet significant. Echter, de resultaten lieten zien dat de ervaren setbacks weldegelijk negatief gerelateerd waren aan maintenance self-efficacy, en dat subjectief succes een negatieve mediërende rol in deze relatie kan hebben. Samengevat, de resultaten suggereren dat de ervaren setbacks kunnen zorgen voor een afname in maintenance self-efficacy en subjectief succes, wat weer zou kunnen leiden tot een toename in het ervaren van setbacks. Deze resultaten hebben gezorgd voor nieuwe inzichten, maar meer onderzoek is nodig naar andere mediërende factoren zoals recovery self-efficacy om het setback effect beter te kunnen begrijpen.Show less
As more environmental challenges arise, pro-environmental engagement becomes increasingly important. While sustainable diets are widely acknowledged for their ecological benefits, the interplay of...Show moreAs more environmental challenges arise, pro-environmental engagement becomes increasingly important. While sustainable diets are widely acknowledged for their ecological benefits, the interplay of social-emotional factors shaping such choices remained relatively underexplored. This study explored the interplay between guilt proneness, emotional support from best friends, and open- mindedness and their influence on young adults’ pro-environmental dietary choices. These variables were selected for their distinct impacts on decision-making processes and behavioural intentions, as guilt proneness motivates alignment with moral values, emotional support provides social reinforcement and validation, and open-mindedness encourages adoption of atypical diets. Plant-based diets involve (mostly) excluding meat including variations like flexitarian and pescetarian diets, while vegetarian diets exclude meat, and vegan diets exclude meat and animal-derived foods and products. The dietary choices in this study rank from the least to the most sustainable diet, being omnivores, plant-based, vegetarian, and ultimately, vegan. The cross-sectional design incorporated 213 individuals aged 17 to 26 from multiple genders and nationalities. The multiple stages assessment included a 45-minute online survey that employed specific tests to assess the factors. Dietary choice was assessed using the Dietarian Identity Questionnaire, guilt proneness using the Test of Self-Conscious Affect–3, emotional support from best friends using the Official short version of the Network Relationship Inventory, and open-mindedness using the Big Five Inventory-2. The multiple regression analyses indicated that guilt proneness, emotional support from best friend, open-mindedness, and the three-way interaction of these variables were non-significant predictors of dietary choice. These results diverged from initial hypotheses, emphasizing the need for exploration within different contexts and populations. The study's strengths included its cross-sectional design encompassing multiple nationalities and genders, and the thorough validation of statistical assumptions. However, the questionable to low reliability of some measures and the unequal gender distribution possibly affected the generalizability of the findings. Additional factors that may influence dietary choices among young adults, including cultural norms, socioeconomic status, anticipated pride, and peer influence, should be incorporated in future research. Interventions aimed at promoting pro- environmental dietary choices among young adults must adopt a holistic approach, considering individual, social, and environmental factors to facilitate long-term behaviour change.Show less
There are numerous people that experience financial hardship. It is important that they get support to get financially back on track. However, they often refrain from seeking help, likely due to...Show moreThere are numerous people that experience financial hardship. It is important that they get support to get financially back on track. However, they often refrain from seeking help, likely due to the shame associated with their financial situation (Keizer, 2016; Plantinga, 2019). This shame hinders their ability to adopt problem-focused coping strategies and consequently improve their financial circumstances (De Hooge et al., 2010). However, shame resilience shows a promising role in addressing this issue. It involves reducing feelings of entrapment, powerlessness, and isolation, thereby managing feelings of shame in a way so that enables people to effectively deal with their situation (Brown, 2006). This study investigates the effectiveness of shame resilience interventions in increasing communication between creditors and debtors. We conducted an experiment involving participants in debt and manipulated creditor letters to increase shame resilience. Results indicate that shame resilience interventions significantly increase willingness to contact creditors and improve the perceived trustworthiness of the company. These findings suggest that applying shame resilience interventions can assist people in taking the first step toward seeking help to address their debt.Show less
Mental health problems such as anxiety and depression among young people are a growing public health problem worldwide. To address this effectively, it’s important to understand to what extend...Show moreMental health problems such as anxiety and depression among young people are a growing public health problem worldwide. To address this effectively, it’s important to understand to what extend factors such as academic stress, parental expectations and family well-being influence the development of anxiety and mood disorders. Relatively little is known about the anxiety and worry experienced by early adolescent children and the extent to which this is culture dependent. The present study sought insight in the worries of children aged 10-12 years from Western and non-Western cultural backgrounds. In addition, the extent to which internalizing symptoms are related to achievement anxiety, parental expectations and family well-being was examined. This was done by interviewing 74 Indian children (M = 10.92 ; SD = 0.75) and 69 Dutch (M = 11.17 ; SD = 0.92) children using the Cultural Formulation Interview. In addition, the amount of internalizing complaints and family welfare were determined using RCADS and FASIII. Results showed that children from India more often experienced achievement-oriented anxiety than Dutch children, and that this was associated with a greater amount of internalizing symptoms. The parental expectations that Indian children experienced were often achievement-oriented expectations regarding school or future profession, whereas the parental expectations of Dutch children were more often focused on being able to show responsibility for tasks. This might be explained by the values transmitted from parent to child within individualistic and collectivistic culture. Evidence exists that cultural values remain present when families from collectivist cultures move to a country with a more individualistic culture. It is therefore extremely important to be aware of these cross-cultural differences within mental health care, as well as education, when dealing with adolescents with anxiety and mood problems.Show less
This study aims to investigate the effects of exercise-intensity on divergent creativity. It is hypothesized that exercise of moderate and high intensity enhance creativity more effectively than...Show moreThis study aims to investigate the effects of exercise-intensity on divergent creativity. It is hypothesized that exercise of moderate and high intensity enhance creativity more effectively than exercise of lower intensity. The study also investigates if arousal, positive high-arousal affect, and negative high-arousal affect serve as intermediary variables in this relationship. Scarce previous research has suggested a relationship between exercise-intensity and creativity, but studies comparing different exercise-intensities on creativity and potential underlying mechanisms were lacking. To address this knowledge gap, this study compares different intensities, namely low-intensity (cycling at 55% of maximum heart rate), moderate-intensity (cycling at 70% of maximum heart rate), high-intensity (cycling at 85% of maximum heart rate) and a control group, on divergent creativity (i.e., number and uniqueness of creative ideas); And looks at affect and arousal as underlying mechanisms. Happy (positive), elated (positive), upset (negative), tense (negative) and stressed (negative) are used as indicators for high-arousal affect and feelings of wakefulness and alertness as indicators for arousal. Participants in this study completed two appointments, of which the first appointment consisted of a fitness test to measure participants’ maximum heart rate. During the second appointment, participants were randomly assigned to one of the four conditions and their affect and arousal were measured before and after the exercise or control task. Creativity was measured after the exercise or control task was completed. A Kruskal-Wallis Test showed that participants in the moderate-intensity and high-intensity exercise did not show higher creativity. Further, macro PROCESS model 4 revealed a significant effect of moderate-intensity and high-intensity exercise on arousal in comparison to low-intensity exercise and a significant effect of moderate-intensity exercise on positive high-arousal affect, in comparison to the control group. Other than this, the model revealed that none of the mediators significantly explained a relationship between exercise-intensity and creativity. This study thus suggests that exercise-intensity does not play a significant role in creativity enhancement, nor does arousal or high-arousal affect. However, future research is needed to confirm this for other modes of exercise, regular exercise instead of acute bouts of exercise and for different individual characteristics, such as age and gender.Show less
Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique showing promise in stroke rehabilitation, with evidence indicating significant enhancement in motor function of...Show moreTranscranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique showing promise in stroke rehabilitation, with evidence indicating significant enhancement in motor function of the contralateral limb following treatment. While TMS appears promising for stroke rehabilitation, there is variability in the level of improvement individuals exhibit. This variability may be attributed to oscillatory neurophysiology, which refers to the rhythmic electrical activity of the brain. Therefore, this study investigated phase-dependent changes in cortical excitability after TMS among stroke patients in affected and unaffected hemispheres. We investigated motor-evoked and TMS-evoked potentials at four phases of the ongoing motor cortical mu rhythm (trough, peak, rising, falling) in both hemispheres (affected, unaffected). Participants comprised N=11 chronic subcortical stroke patients (6 female, mean ± std age: 58 y ± 11.4) with affected lateralized upper-limb impairment. Four blocks of 150 TMS pulses were applied on each hemisphere, targeting the primary motor hotspot of the first dorsal interosseus muscle of the contralateral hand. Participants watched nature videos during stimulation to maintain consistent attention levels. Cortical excitability was assessed by analyzing motor-evoked potentials (MEP) and TMS-evoked potentials (TEP). Results showed that motor responses (measured through MEP amplitudes) were significantly larger at the trough and rising phase compared to the peak phase. No significant differences were observed between the affected and unaffected hemispheres. TEP components, the brain signals in response to TMS, did not exhibit significant phase-dependent changes. While our findings showed a nonsignificant effect of stroke severity, exploratory correlation analyses presented a positive association between higher remaining movement function and enhanced phase-dependent responses to TMS. The findings build upon previous research indicating phase-dependent changes in cortical excitability for MEPs but not for TEPs. The larger MEP amplitudes during trough and rising phases suggest that TMS can be more effective at specific points of cortical activity. Further exploration is needed to assess the efficacy of phase-specific TMS interventions in clinical settings, potentially through larger-scale clinical trials with longitudinal designs and comparative effectiveness studies, aiming to evaluate functional outcomes and determine their impact on motor recovery.Show less
