Klinefelter Syndrome (KS; 47, XXY) is a sex chromosome aneuploidy that affects male physical, cognitive and psychological development. KS has been related to difficulties in social interactions and...Show moreKlinefelter Syndrome (KS; 47, XXY) is a sex chromosome aneuploidy that affects male physical, cognitive and psychological development. KS has been related to difficulties in social interactions and executive dysfunctions. This study investigates several executive functions (inhibition, cognitive flexibility, planning, working memory and sustained attention), social skills and the relationship between these two variables in men with KS. Eighteen men with KS and 29 controls between the age of 16 and 60 years old, participated in this study. Social skills were measured by the Social Responsiveness Scale rated by informants (SRS-A). Executive functions were assessed by the Behavior Rating Inventory of Executive Function (BRIEF) questionnaire and by tasks of the Amsterdam Neuropsychological Tasks (ANT) and by one task of the Behavioral Assessment of the Dysexecutive Syndrome (BADS-NL). The clinical group rated poorer social skills than the controls. They also had weaker executive functions compared by controls (measured by the BRIEF). The ANT tasks revealed that from the executive functions, the Klinefelter group only had more difficulties in sustained attention compared by controls. Working memory was significantly (positively) correlated to social skills. The present findings suggest that KS is related to executive dysfunctions measured by the BRIEF and a weak working memory was related to poorer social skills. The results from this study provided insight in which cognitive structure is related to social skills in male with KS and could thereby contribute in the treatment and prevention of problems in social skills.Show less