In the past decades, methylphenidate has gained widespread popularity onto the pharmacological market, directed toward individuals with a diagnosis of Attention-deficit/hyperactivity disorder (ADHD...Show moreIn the past decades, methylphenidate has gained widespread popularity onto the pharmacological market, directed toward individuals with a diagnosis of Attention-deficit/hyperactivity disorder (ADHD), narcolepsy, traumatic brain injury, stroke, and even human immunodeficiency virus infections. This cognitive enhancer exerts its effects by binding to the dopamine transporter, resulting in heightened extracellular dopamine levels. However, the psychophysiological side-effects associated with this medication are not yet fully understood. The present study delves deeper into erratic psychophysiological side-effects, including psychosis, mood changes, experiences of seizures, tics and the development of skin rashes. Our primary objectives were twofold. Firstly, we aimed at exploring the frequency of adverse symptom perception in individuals receiving methylphenidate as treatment. Secondly, we sought to investigate the potential impact of treatment duration on symptom perception, and examine any potential correlation between the two. To achieve this, we implemented an online version of ‘The Methylphenidate monitoring side effects scale’ (MMSES), with a total of 135 participants, 22 belonging to the experimental group, with prescribed medication, and 113 to the control group, not receiving medication. The results of our study revealed that adverse symptom perception did not significantly differ between the experimental and the control group, (t = 0.31, p = .852). However, psychotic symptoms were significantly lower in the control group in comparison to the experimental group (t = 0.56, p = .041). Additionally, the correlational analysis demonstrated a non-significant relationship between treatment duration and symptom perception (r(20) = .21, p = .353). These preliminary findings need to be followed up by future research and require to be interpreted with caution due to a possibly confounding effect of age differences and other limitations. Future directions may comprise the inclusion of neuroimaging techniques to identify the pathophysiological changes associated with methylphenidate administration, and a larger sample size.Show less
