Background and aim: Although literature suggests that quality of life (QoL) in women with substance use disorders (SUDs) is lower than in men, it remains unknown whether this 1) applies to SUD...Show moreBackground and aim: Although literature suggests that quality of life (QoL) in women with substance use disorders (SUDs) is lower than in men, it remains unknown whether this 1) applies to SUD patients with psychiatric comorbidities in the Netherlands; and 2) whether there is a gender difference in QoL gain during treatment. This study therefore aimed to compare QoL (gain) between genders. Because research linked mood problems to worse QoL and substance usage in women, it was also the aim to compare genders in the association between (change in) mood problems and (change in) QoL. Methods: The longitudinal design involved data of day-patient treatments between 2018-2020. Sixty nine females and one hundred and thirty males with SUDs and comorbidities were assessed, using the EQ-5D-3L and the ICECAP-A. Analysis of variance and moderation analyses were performed with multiple imputation, controlling for treatment group. Results: At pretest, QoL in women was significantly lower when compared to men. There was no significant gender difference concerning gain in QoL, as well as regarding the association between mood problems and QoL at pretest and posttest. Conclusions: Women with SUDs and comorbidities experience lower QoL than men, a gender gap that is less profound in the normal population. Stigma and adverse life conditions arguably play a role. There is no evidence that men and women profit differently from treatment. In any case, mood problems, trauma experiences and meaningful activities could be considered more in future studies, as their association with QoL seems to be critical.Show less
