Research master thesis | Psychology (research) (MSc)
open access
Bullying victimization is a major public health concern, because victims often experience long-term negative mental health outcomes. Longitudinal brain structure research in children is needed to...Show moreBullying victimization is a major public health concern, because victims often experience long-term negative mental health outcomes. Longitudinal brain structure research in children is needed to understand the possible mechanisms underlying the relation between bullying victimization and negative mental health outcomes. Previous research has shown that the fusiform gyrus, amygdala and vmPFC are impaired in victims. Therefore, this thesis examined the relation between victimization and fusiform gyrus, amygdala and vmPFC volume over time. We hypothesized that victims of bullying, compared to children uninvolved in bullying, would have a larger fusiform gyrus volume and a steeper volume increase. Furthermore, we hypothesized that victims of bullying, compared to children uninvolved in bullying, would have a smaller amygdala and vmPFC volume and a steeper volume decrease. The sample consisted of 156 children (62% female), aged between 7 and 9 years old at baseline, from the Leiden Consortium on Individual Development. At the beginning of the study, the Revised Olweus Bully/Victim Questionnaire was administered to measure bullying victimization and high-resolution structural MRI scans were taken. This was done again two years later. Children were classified as victims if they had been bullied regularly in the past two months. We did not find an effect of victimization on fusiform gyrus, amygdala and vmPFC volume. Future research examining the influence of victimization on both structural and functional brain development is needed to provide further insights, which can help inform the design of interventions to reduce the negative consequences of bullying victimization. The current findings emphasize the importance of protective factors that make a victim’s brain development resilient against victimization. This indicates a need for interventions targeting the development of social-emotional skills or the increase of family support.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Adolescence is characterized by the onset of puberty. Puberty, in turn is shown to be a driver of brain development and has been related to the onset and increase of internalizing symptoms. However...Show moreAdolescence is characterized by the onset of puberty. Puberty, in turn is shown to be a driver of brain development and has been related to the onset and increase of internalizing symptoms. However, the relationship between puberty, brain development, and internalizing symptoms has not been studied using multiple pubertal measures in both sexes. Here we examine the mediating role of brain development on the relationship between puberty and internalizing symptoms. Pubertal status, timing, age at menarche, and internalizing symptoms were assessed based on self-reports in 160 adolescents between 10 and 25 using a three-wave accelerated longitudinal design. Structural MRI scans were only obtained in the first wave. Subsequently, the relations between the pubertal measures (status, timing, age at menarche) and internalizing symptoms were tested as well as their relations with grey matter thickness and volume in frontal, cingulate, and subcortical areas. Only age at menarche as a timing variable had a significant effect on internalizing symptoms at T1 in girls (ß = -.36, p = .002, 95% CI [-.68, -.17]). Mediation models revealed no significant mediation of grey matter thickness and volume in our ROIs. Other effects did not reach significance or became non-significant after Bonferroni corrections. These findings indicate that menstruating before one’s peers is a risk factor for developing internalizing symptoms. This highlights the importance of supporting early menstruating girls to possibly prevent them from developing internalizing symptoms. Replication studies are needed to assess the accuracy of our results.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Building on evidence that minority representation increases minorities’ political participation, in my preregistered study, I investigated whether increased racial representation within the climate...Show moreBuilding on evidence that minority representation increases minorities’ political participation, in my preregistered study, I investigated whether increased racial representation within the climate movement causes Americans of color (N = 226) to evaluate the climate movement more positively and to encourage them to partake in climate activism. I tested this by using a 2 x 2 between-subjects design in which representation was manipulated both descriptively (i.e., the presence of people of color) and substantively (i.e., a focus on issues specifically affecting people of color) in a short video about climate activism. The results showed that descriptive representation had a positive, significant effect on evaluation of the movement, but no effects were found for substantive representation nor on climate action behavior. These findings enrich the scientific literature and provide insights on how social movements can become more inclusive, potentially increasing their effectiveness.Show less
Research master thesis | Psychology (research) (MSc)
under embargo until 2026-03-29
2026-03-29T00:00:00Z
Relevance: Efficacy of doctor empathy and nocebo education on treatment outcomes of people with cancer has been established across experimental and randomised-controlled trials (RCT). Objective: i)...Show moreRelevance: Efficacy of doctor empathy and nocebo education on treatment outcomes of people with cancer has been established across experimental and randomised-controlled trials (RCT). Objective: i) to test whether distinct effects of clinician empathy and nocebo information can also improve psychological and side effect outcomes of clinical advanced breast cancer patients undergoing chemotherapy and ii) to explore whether potential positive effects are persistent over treatment time. Methods: In this 2x2 proof-of-principle study, before treatment start, a total of 23 Dutch, chemonaïve, female breast cancer patients undergoing chemotherapy were randomised (1:1:1:1) to short information videos on chemotherapy side effects. The four videos varied on levels of empathy (+ / -) and nocebo information (+ / -). During treatment, participants’ psychological (primary outcomes: anxiety, distress) and side effect outcomes were assessed by self-report questionnaires at 7-days, 21-days, and 52-days after treatment start. Results: Repeated linear mixed model analyses indicated that empathy generally did not affect the level of anxiety (p = .440) or distress (p = .056). Empathy increased overall intensity (β = 0.76, 95% CI [.07; 1.44], p = .032) and number of side effects (β = 0.78, 95% CI [.11; 1.45], p = .025). Nocebo information did not seem to influence intensity (p = .269) or number of side effects (p = .975). Only anxiety levels were indicated to increase over time (p = .008), both at 21-days (β = 0.86, 95% CI [.25; 1.47]) and 52-days (β = 1.18, 95% CI [.38; 1.98]) post-treatment start. Conclusions: In clinical settings, advanced breast cancer patients may not profit from empathy or nocebo information. Repeating the study with a larger sample is recommended to gain clarity on communication effects. The information videos may benefit training of clinical staff and treatment consultations.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Cooperation and competition are important aspects of group behavior that have been well-researched in social psychology, but the relation between these elements has not been investigated to a...Show moreCooperation and competition are important aspects of group behavior that have been well-researched in social psychology, but the relation between these elements has not been investigated to a comparable degree. While competition between groups is known to increase cooperation within groups, the precise magnitude of its influence is not clear. Theoretically-relevant moderators that could influence this relationship have been left largely unexplored, and influential methods of studying cooperation and competition have not been assessed. Therefore, in this pre-registered meta-analysis, we investigated the impact of between-group interactions, including outright between-group competition and situations where groups compare their performance to other groups, on within-group cooperation. We conducted a systematic review of the literature involving economic games that compare cooperation in the presence of an intergroup interaction to cooperation within single groups. We compiled 17 relevant studies which yielded 47 effect sizes. Our multilevel random effects model revealed a small-to-medium, positive effect of intergroup interaction on within-group cooperation (g = 0.505, N = 4187). Confirmatory moderator analyses indicated that males, compared to females, invested more in within-group cooperation during intergroup interactions than in single, isolated groups. Additionally, effects involving intergroup comparison were weaker than effects featuring intergroup competition. Exploratory moderator analyses revealed that several variations in the methods of study impact the effect on within-group cooperation (e.g. deception, decision type, and participant matching). Our findings present compelling meta-analytic evidence that intergroup competition has a reliable impact on cooperation, and raises several opportunities for future research.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Avoidance is a hallmark symptom of Post-Traumatic Stress Disorder (PTSD), yet the link between avoidance learning and PTSD severity and treatment outcome has not yet been explored. For this purpose...Show moreAvoidance is a hallmark symptom of Post-Traumatic Stress Disorder (PTSD), yet the link between avoidance learning and PTSD severity and treatment outcome has not yet been explored. For this purpose, we administered a computer-based avoidance learning task to 144 treatment-seeking PTSD patients during the baseline assessment of a randomized clinical trial. The task consisted of a photo of blue or red colored lamps (conditional stimuli, CS+) followed by aversive photos (unconditional stimulus, US), while a photo of a yellow-colored lamp was followed by a black screen (safety stimulus, CS-). The US could be avoided by pressing a button during one CS+ (CS+ avoidable) but not the other (CS+ unavoidable). Participants were asked to fill in a threat expectancy rating after the CSs, and to report their relief after omission of the US. Participants were then given exposure therapy, and their PTSD symptoms were measured throughout 52 weeks. We predicted that higher rates of unnecessary or ineffective avoidance, higher expectancy ratings after omission of the US, and higher relief scores would relate to higher PTSD severity, and lower treatment gains. Results did not confirm any hypothesis; however, elevated threat expectancies (regardless of CStype) were related to PTSD symptom severity at baseline, and expectancies following CS- were related to PTSD severity across time points. Findings suggest general impairment in action-safety learning; however, it might be more relevant in light of PTSD severity to further explore the role of general threat expectancy. Furthermore, future studies should consider utilizing physiological measures, and adapting the task to include avoidance costs.Show less
Research master thesis | Psychology (research) (MSc)
closed access
In this study we investigated the relationship between stress, prosociality, and academic achievement. With a sample of UK-based college students, we aimed to investigate whether prosociality may...Show moreIn this study we investigated the relationship between stress, prosociality, and academic achievement. With a sample of UK-based college students, we aimed to investigate whether prosociality may serve as a buffer for the assumed negative relationship between stress and academic achievement. Our findings revealed that there was a negative relationship between academic stress and academic achievement. Furthermore, people tended to be more prosocial when they were stressed. However, this increased prosociality was not related to academic achievement and did not buffer people’s academic achievement from the negative effects of stress. The findings highlight the complex dynamic between stress, prosociality, and academic achievement. Understanding the interplay between these three variables has significant value for the innovation of interventions and preventive measures to enhance the overall well-being in students.Show less
Research master thesis | Psychology (research) (MSc)
under embargo until 2026-02-27
2026-02-27T00:00:00Z
Food waste is a big problem in the Netherlands. In an effort to find a solution to this problem, the present study examines the influence of expiration date labels on people’s intention to waste...Show moreFood waste is a big problem in the Netherlands. In an effort to find a solution to this problem, the present study examines the influence of expiration date labels on people’s intention to waste food. The current phrase “ten minste houdbaar tot” [“at least preservable until”] can be seen as definitive and thought to refer to food safety whereas it refers to food quality, thus this study proposes an alternative phrase “beste kwaliteit voor, vaak goed na” [“best quality before, often good after”]. The aim of this alternative phrase was to make clear that the expiration date refers to food quality and that the food could still be safe to consume after this date had passed. Participants were presented with dairy and pantry products that had an expiration date that had passed by five days. This expiration date was shown with the current phrasing or the alternative phrasing. Results showed that the alternative phrase led to a lower intention to waste dairy compared to the current phrase. Whereas for pantry products, there was no difference in intention to waste food between the two phrases. Moreover, results showed that the intention to waste dairy was mediated by perceived risk. Meaning that dairy products that were presented with the alternative phrase were perceived as less risky to consume, which in turn was associated with a lower intention to let the product go to waste when the expiration had passed. Thus, changing the phrasing of the expiration date label could help in reducing food waste in the Netherlands.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Language control in bilingual speakers involves effectively switching between languages, inhibiting the non-intended language, and continuously monitoring speech errors. It has been a matter of...Show moreLanguage control in bilingual speakers involves effectively switching between languages, inhibiting the non-intended language, and continuously monitoring speech errors. It has been a matter of controversy concerning whether language control operates in a comparable manner to cognitive control processes in non-linguistic domains (domain-general) or if it is exclusive to language processing (domain-specific). Midfrontal theta oscillations have been considered as an index for increased cognitive control, so examining whether a similar midfrontal theta effect is likewise evident in bilingual language will bring new insights to the ongoing debate. This study aimed to explore midfrontal theta oscillations in bilingual control with a specific focus on three fundamental control processes: language switching, inhibitory control, and speech monitoring. We reanalysed the EEG data obtained from two previous language switching studies where Dutch-English bilinguals named pictures based on colour cues. Theta power increase was observed during language switching, specifically in switch trials compared to repeat trials, and this effect was observed in the midfrontal region. Similarly, enhanced midfrontal theta power was observed during error monitoring, specifically when participants failed to select the intended language at a switch, compared to correct responses. However, no midfrontal theta effect was found during inhibitory control, reflected by a missing modulation in switch trials following a short run (i.e., a short sequence of same-language repeat trials) compared to a long run (i.e., a long sequence of same-language repeat trials). These findings largely support the involvement of domain-general cognitive control mechanisms in language control, particularly in language switching and speech monitoring, whereas inhibitory control remains unclear.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Mobile applications with a virtual coach providing real-time relapse-prevention support may be useful to aid smoking cessation as they are easily accessible, cost-effective, and can be utilized...Show moreMobile applications with a virtual coach providing real-time relapse-prevention support may be useful to aid smoking cessation as they are easily accessible, cost-effective, and can be utilized directly in situations where the risk of relapse is high. This study aimed to examine the effect of three types of relapse-prevention support on tobacco craving to inform the development of a mobile application with a virtual coach. The three types of support focused on (A) motivation and self-efficacy; (B) one’s future self and implementation intentions; and (C) identity-related positive self-talk. Secondly, the study aimed to explore how physical nicotine dependence related to the effect of relapse-prevention support on tobacco craving. A virtual reality experiment with a within-participant design was conducted where 25 participants intending to quit smoking were immersed in a virtual high-risk-of-smoking environment. The participants had four conversations in a randomized order with a concept version of a virtual coach on a simulated mobile phone: three conversations containing a type of relapse-prevention support and one neutral conversation. Physical nicotine dependence was measured at baseline and craving was measured after each conversation. Participants indicated that they would find it reasonably difficult to refrain from smoking in the VR environment and sense of presence was sufficient. Results indicated that the relapse-prevention support did not decrease craving compared to neutral contact with the coach. Furthermore, no association was found between physical nicotine dependence and effect of relapse-prevention support. These results stress the need for evaluations of effectiveness in order to inform the further development and improvement of the relapse prevention support prior to finalizing a mobile application with a virtual coach.Show less
Research master thesis | Psychology (research) (MSc)
under embargo until 2026-01-31
2026-01-31T00:00:00Z
Language control in bilingual speakers involves effectively switching between languages, inhibiting the non-intended language, and continuously monitoring speech errors. It has been a matter of...Show moreLanguage control in bilingual speakers involves effectively switching between languages, inhibiting the non-intended language, and continuously monitoring speech errors. It has been a matter of controversy concerning whether language control operates in a comparable manner to cognitive control processes in non-linguistic domains (domain-general) or if it is exclusive to language processing (domain-specific). Midfrontal theta oscillations have been considered as an index for increased cognitive control, so examining whether a similar midfrontal theta effect is likewise evident in bilingual language will bring new insights to the ongoing debate. This study aimed to explore midfrontal theta oscillations in bilingual control with a specific focus on three fundamental control processes: language switching, inhibitory control, and speech monitoring. We reanalysed the EEG data obtained from two previous language switching studies where Dutch-English bilinguals named pictures based on colour cues. Theta power increase was observed during language switching, specifically in switch trials compared to repeat trials, and this effect was observed in the midfrontal region. Similarly, enhanced midfrontal theta power was observed during error monitoring, specifically when participants failed to select the intended language at a switch, compared to correct responses. However, no midfrontal theta effect was found during inhibitory control, reflected by a missing modulation in switch trials following a short run (i.e., a short sequence of same-language repeat trials) compared to a long run (i.e., a long sequence of same-language repeat trials). These findings largely support the involvement of domain-general cognitive control mechanisms in language control, particularly in language switching and speech monitoring, whereas inhibitory control remains unclear.Show less
Research master thesis | Psychology (research) (MSc)
closed access
The present research investigated the association between Machiavellianism and different behavioural responses in a novel economic game. The main purpose of the research was to reveal the patterns...Show moreThe present research investigated the association between Machiavellianism and different behavioural responses in a novel economic game. The main purpose of the research was to reveal the patterns of behaviours associated with the Machiavellian personality in a setting in which acting in a cooperative and competitive manner are both feasible options.The results of the research suggest that there is a negative association between Machiavellianism and cooperation. Individuals with higher level of Machiavellianism tended to invest more resources to competition, relative to cooperation. No association was found between Machiavellianism and choosing peace in the economic game. Lastly, performance in the game could, also, not be predicted by one’s Machiavellian inclinations. We can conclude that, even when given the possibility to compete and cooperate at the same time, Machiavellians still tend to exhibit a higher propensity towards non-cooperative responses and a slightly higher propensity towards competitive behaviours compared to low Machiavellians.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Prediction-based learning is an effective teaching method for building factual knowledge, i.e., semantic learning. Its effectiveness likely depends on its potential to elicit surprise in learners....Show morePrediction-based learning is an effective teaching method for building factual knowledge, i.e., semantic learning. Its effectiveness likely depends on its potential to elicit surprise in learners. Only a few studies tested this hypothesis using a prediction-based learning framework comparable to semantic learning in the classroom. Most of these studies used physiological measures of surprise. However, the link between prediction-based semantic learning and learners' metacognitive surprise remains to be investigated. Using mixed models, we tested and explored to what degree participants' (N = 41; Mage = 21.9 years, SD = 1.5, 73% female) metacognitive surprise about the learning material (numerical trivia facts) explained how well participants learned (continuous metric) and recalled (binary metric) this material during a numerical-fact learning task designed to resemble classroomlike prediction-based learning. In line with our hypothesis, preregistered analyses showed that the more surprising participants found a fact, the more they learned from it. Extending previous work, we found that this link remained when controlling for a) between-fact differences in learning potential and b) facts already known to the participants and when c) participants failed to recall a fact correctly. Further extending previous work, our exploratory analyses suggested that learning also improved when participants perceived the facts as nonsurprising. So, the link between metacognitive surprise and learning may be u-shaped rather than linear. Altogether, these findings hint that learners'surprise about the learning material is one of the factors explaining to what degree learners learn from their prediction mistakes to update their factual knowledge. We forgo conclusions about the link between metacognitive surprise and recall accuracy since the confirmatory and exploratory results were ambiguous and negligibly small.Show less
Research master thesis | Psychology (research) (MSc)
under embargo until 2024-12-22
2024-12-22T00:00:00Z
Social anxiety disorder (SAD) is a disorder characterized by impairments in interpersonal functioning such as experiencing difficulties in forming and maintaining relationships. These impairments...Show moreSocial anxiety disorder (SAD) is a disorder characterized by impairments in interpersonal functioning such as experiencing difficulties in forming and maintaining relationships. These impairments have negative intrapersonal consequences for individuals with SAD on different levels such as the physiological, behavioral, and psychological level. A newer perspective on SAD has suggested that it also negatively impacts the interaction partner (i.e. interpersonal consequences of the disorder). According to this perspective, certain verbal and nonverbal behaviors and thought or feeling content of the healthy interaction partner are affected while interacting with an individual who have SAD. The current study investigated the intra- and interpersonal consequences of SAD on the physiological, behavioral, and psychological level during initial interactions. Participants played a dyadic trust game (23 same-gender dyads) while their electrodermal activity (EDA) was continuously measured and filled in self-report measures during and after the game. The dyads consisted either of one participant scoring high on social anxiety (SA) and one low on SA (i.e. SA dyads) or two participants scoring low on SA (i.e. control dyads). EDA was used as the measure on the physiological level, participants’ trust ratings were the measure on the behavioral level, and the discrepancy between self and partner reports on positive/negative personal attributes to explore cognitive biases was the measure on the psychological level. We expected to observe higher EDA synchrony, lower trust ratings, and higher discrepancy between self and partner reports in SA dyads compared to control dyads. Results showed no difference between dyads on all levels indicating that we were not able to observe the predicted effect of finding intra- and interpersonal consequences of SAD in SA dyads. The most important implication of the current study is that, it included three different levels of SAD, in contrast to earlier studies that mainly focused on one level. This provides a useful example for how future studies might be designed and conducted.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Background: about 5% of children experience childhood parental death, which has been associated with a higher risk for developing insecure attachment styles in adulthood. However, some people...Show moreBackground: about 5% of children experience childhood parental death, which has been associated with a higher risk for developing insecure attachment styles in adulthood. However, some people suffer more long-term consequences compared to others, even within the same family. Which factors play a role in the differential experiences following childhood parental death, even between siblings, who experienced the same objective life event? Objective: In the current study, we aimed to investigate the association between childhood parental death and adult attachment, and the role of parental bonding with each parent in this association. We also investigated this in a sibling-context, where we studied parental bonding as a family-wide and an individual factor. Design: 819 participants, aged between 25 and 45 years old, took part in this cross-sectional between-subject study. Questionnaires were administered to obtain information about parental bonding and adult attachment. The study included two parts, where in the first part the hypotheses were investigated in the main sample (i.e., a sample of nonrelated individuals), an in the second part in the sibling sample (i.e., a sample of sibling dyads and triads). Results: Both avoidant and anxiety attachment were more present in the target group compared to the control group in the main sample, but not in the sibling sample. Stronger maternal and paternal bonding were related to less insecure attachment in adulthood in the control group of the main sample, but no associations between bonding with the surviving and deceased parent were found the target group of the main sample. Stronger family-wide and individual maternal bonding were related to less avoidance attachment in the control group of the sibling sample, but not to anxiety attachment. In the target group of the sibling sample, stronger family-wide bonding with the surviving parent was related to less avoidance attachment and stronger family-wide bonding with the deceased parent was related to less anxiety attachment. Conclusion: Childhood parental death appears to be related to more insecure attachment in adulthood. The role of parental bonding seems to be different depending upon whether childhood parental death has been experienced. Within siblings, both familywide parental bonding and individual specific bonding seem to have individual effects on adult attachment, suggesting that including individual and family-wide experiences might shed light upon more complex processes of bonding and attachment formation within families. However, further research is needed to replicate these findings before conclusions can be drawn.Show less
Research master thesis | Psychology (research) (MSc)
closed access
When learning new information, generating a prediction before receiving the information strongly improves the amount of learning. To this date, the mechanisms underlying why generating predictions...Show moreWhen learning new information, generating a prediction before receiving the information strongly improves the amount of learning. To this date, the mechanisms underlying why generating predictions increases learning are poorly understood. One potential factor that influences this effect is surprise: more surprising information has been demonstrated to deepen information processing when the information differs from our expectations, which occurs when we cannot explain the new information through our belief systems. However, too much surprise may be adverse to learning, as the information may be flagged as implausible and consequently be rejected from our belief network (Munnich & Ranney, 2019). In this study, we investigated the influence of surprise and plausibility on a numerical fact-learning task using three different kinds of learning outcomes: recall, recognition, and memory updating. Using multilevel modelling, we found a nonlinear influence of surprise on immediate recall, as well as a linear influence of surprise on the updating of beliefs. We did not find a significant association between surprise and delayed recognition, nor any significant effects of plausibility on the three measures of learning, although there appeared to be a trend effect of plausibility on the updating of beliefs. Future research should further investigate when newly presented information gets rejected from belief systems, and the role that implausibility of information plays in this phenomenon.Show less
Research master thesis | Psychology (research) (MSc)
closed access
Patients with Duchenne muscular dystrophy (DMD) lack the full-length dystrophin protein. In muscle this protein contributes to membrane integrity. It is also found in the brain, but its function...Show morePatients with Duchenne muscular dystrophy (DMD) lack the full-length dystrophin protein. In muscle this protein contributes to membrane integrity. It is also found in the brain, but its function there is unclear. Patients with DMD experience a number of cognitive and behavioral problems, and MRI studies have shown reduced gray matter and total brain volume. The current study aimed to assess whether these MRI findings are progressive and whether neural correlates of psychological problems in DMD are similar to those in healthy controls. Previously-acquired pediatric data was combined with newly-acquired data from adult DMD patients and age- and sex-matched healthy controls. Subjects underwent a magnetic resonance imaging scan and a neuropsychological evaluation. Linear mixed models were used to assess the effect of age and DMD on the ratio of gray matter to cerebrospinal fluid volume (GMV:CSFV) and total brain volume corrected for intracranial volume (TBV:ICV). An independent-samples t-test and a voxel-based morphometry analysis were used to compare gray matter volume in patients with psychological problems to patients without such problems, to identify global or local gray matter reductions in patients with psychological problems. Patients with DMD had reduced GMV:CSFV and TBV:ICV compared to healthy controls (b=-0.43, p<0.001; b=-0.02, p<0.001 respectively). Both GMV:CSFV and TBV:ICV linearly decreased in both groups (b=-0.09, p<0.001; b=-0.003, p<0.001 respectively), but this was not different between-groups (p>0.05). No global (p>0.05) or localized gray matter volume reductions were found in patients with DMD with psychological problems compared to patients without such problems. In both patients and healthy controls gray matter was displaced by cerebrospinal fluid over time, suggesting this process is not a pathological mechanism in DMD. Patients with DMD did have a lower GMV:CSFV and TBV:ICV ratio, suggesting this is a diseased mechanism. No global or local GM reductions were found in patients with DMD with psychological problems compared to patients without such problems.Show less
