Transcranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique showing promise in stroke rehabilitation, with evidence indicating significant enhancement in motor function of...Show moreTranscranial magnetic stimulation (TMS) is a noninvasive neuromodulation technique showing promise in stroke rehabilitation, with evidence indicating significant enhancement in motor function of the contralateral limb following treatment. While TMS appears promising for stroke rehabilitation, there is variability in the level of improvement individuals exhibit. This variability may be attributed to oscillatory neurophysiology, which refers to the rhythmic electrical activity of the brain. Therefore, this study investigated phase-dependent changes in cortical excitability after TMS among stroke patients in affected and unaffected hemispheres. We investigated motor-evoked and TMS-evoked potentials at four phases of the ongoing motor cortical mu rhythm (trough, peak, rising, falling) in both hemispheres (affected, unaffected). Participants comprised N=11 chronic subcortical stroke patients (6 female, mean ± std age: 58 y ± 11.4) with affected lateralized upper-limb impairment. Four blocks of 150 TMS pulses were applied on each hemisphere, targeting the primary motor hotspot of the first dorsal interosseus muscle of the contralateral hand. Participants watched nature videos during stimulation to maintain consistent attention levels. Cortical excitability was assessed by analyzing motor-evoked potentials (MEP) and TMS-evoked potentials (TEP). Results showed that motor responses (measured through MEP amplitudes) were significantly larger at the trough and rising phase compared to the peak phase. No significant differences were observed between the affected and unaffected hemispheres. TEP components, the brain signals in response to TMS, did not exhibit significant phase-dependent changes. While our findings showed a nonsignificant effect of stroke severity, exploratory correlation analyses presented a positive association between higher remaining movement function and enhanced phase-dependent responses to TMS. The findings build upon previous research indicating phase-dependent changes in cortical excitability for MEPs but not for TEPs. The larger MEP amplitudes during trough and rising phases suggest that TMS can be more effective at specific points of cortical activity. Further exploration is needed to assess the efficacy of phase-specific TMS interventions in clinical settings, potentially through larger-scale clinical trials with longitudinal designs and comparative effectiveness studies, aiming to evaluate functional outcomes and determine their impact on motor recovery.Show less
Voorgaande onderzoeken tonen dat heteroseksuele mannen beter presteren op navigatietaken dan heteroseksuele vrouwen, homoseksuele vrouwen en homoseksuele mannen. Het huidige onderzoek bekijkt het...Show moreVoorgaande onderzoeken tonen dat heteroseksuele mannen beter presteren op navigatietaken dan heteroseksuele vrouwen, homoseksuele vrouwen en homoseksuele mannen. Het huidige onderzoek bekijkt het effect van seksuele oriëntatie, gender en geslacht op de prestatie op een navigatietaak. Het onderzoek verspreidde een online vragenlijst met navigatietaak onder 216 deelnemers met een gemiddelde leeftijd van 27 jaar oud. 65 van de deelnemers waren van het mannelijke geslacht en 151 van het vrouwelijke geslacht. Hiervan waren 151 deelnemers heteroseksueel en 65 niet-heteroseksueel. Uit de resultaten van het onderzoek bleek dat seksuele oriëntatie, gender en geslacht geen effect hebben op de prestatie van mensen op een navigatietaak. Dit kan komen door de kleine individuele groepen binnen de niet-heteroseksuelen, waardoor er geen goede conclusie over de aparte groepen getrokken kan worden. Toekomstige onderzoeken zouden meer LHBTQIA+ organisaties kunnen betrekken bij het werven van deelnemers.Show less
Het verwerven van kennis en informatie ligt aan de basis van veel belangrijke levensuitkomsten. Het beïnvloedt beslissingen, gedragingen en het draagt ook bij aan de ontwikkeling en het in stand...Show moreHet verwerven van kennis en informatie ligt aan de basis van veel belangrijke levensuitkomsten. Het beïnvloedt beslissingen, gedragingen en het draagt ook bij aan de ontwikkeling en het in stand houden van welbevinden. Echter kan te veel of ambigue informatie ook ongewenste effecten teweegbrengen, zoals verhoogde angst en stress. Het is daarom van belang dat zowel het verwerven als het verstrekken van informatie zo adaptief mogelijk genavigeerd kan worden. Vooral voor een populatie die al te maken heeft met verhoogde aanwezigheid van stressoren en angst zoals mensen met een laag sociaaleconomische status. Door middel van een online vragenlijst waarbij informatie-zoekend gedrag, sociaaleconomische status en angst onderzocht werden, bleek de sociaaleconomische status geen effect te hebben op informatie-zoekend gedrag, en was er ook geen significante moderatie van angst. De resultaten suggereren dat de sociaaleconomische status en het persoonlijkheidskenmerk angst geen invloed hebben op informatie-zoekend gedrag. Mogelijke verklaringen kunnen onder andere zijn dat het construct van sociaaleconomische status niet uitputtend is gemeten. En dat angst de relatie alleen modereert wanneer grote veranderingen plaatsvinden en niet met meer geleidelijke veranderingen, wat in lijn is met eerder onderzoek. Dit onderzoek draagt bij aan de inzichtelijkheid van de verschillende dimensies die onderdeel zijn van sociaaleconomische status, informatie-zoekend gedrag en angst.Show less
There is increasing evidence for the negative effect of external aid programs on public health. Accordingly, it is essential to research how donors could effectively allocate their aid. It is...Show moreThere is increasing evidence for the negative effect of external aid programs on public health. Accordingly, it is essential to research how donors could effectively allocate their aid. It is established that institution-building in the health sector is crucial for enhancing public health, for example by fostering accountability and transparency. Aid that is spent on institution-building is expected to have a positive effect on public health. However, there is no empirical evidence for that, and therefore, this research contributes to the existing literature by answering the following research question: What is the effect of aid targeting institution building in the health sector on public health outcomes? Several linear regressions are performed to test the effect of Official Development Assistance for institution-building in the health sector on infant mortality, life expectancy, and immunization rates. The overall research findings show a positive, but small and insignificant relationship between health institutional aid and public health.Show less
Background. Emergency department (ED) nurses are prone to develop burnout, however, they also tend to be engaged in their work. The goals of this study were twofold: (1) to establish the frequency...Show moreBackground. Emergency department (ED) nurses are prone to develop burnout, however, they also tend to be engaged in their work. The goals of this study were twofold: (1) to establish the frequency of ED nurses in four burnout - work engagement profiles, and (2) to investigate which work characteristics best separated the four burnout – work engagement profiles. Method. A cross-sectional study was done among 967 ED nurses working in one of 28 hospitals in the Netherlands (response rate 74%). The data was gathered using an online questionnaire. A frequency analysis and a descriptive discriminant analysis were performed. Two separate analyses were done for emotional exhaustion and depersonalization. Results. For emotional exhaustion, the engaged profile was most prevalent among the ED nurses in this sample, followed by the burnout, unengaged and engaged-burnout profiles. For depersonalization, the engaged profile was also most prevalent, followed by the burnout, engaged-burnout and unengaged profiles. Two functions were generated by the descriptive discriminant analysis: (1) the Job Demands-Resources (JDR) function and (2) the mastery function. The JDR function separated the burnout from the engaged profile. When nurses scored high on job demands and low on job resources, they were more likely to be in the burnout profile, and vice versa for the engaged profile. Work-time demands and autonomy were primarily responsible for group separation for burnout overall. For emotional exhaustion staffing was also primarily important, whereas for depersonalization, educational and developmental possibilities and (financial) appreciation were also primarily important for group separation. The mastery function separated the engaged-burnout from the unengaged profile. When nurses had educational and developmental possibilities, and experienced a higher frequency of emotionally demanding and conflict/aggression situations, they were more likely to be in the engaged-burnout profile, and vice versa for the unengaged profile. Conclusion. This study provided insight in the interplay between burnout, work engagement, job demands and job resources. This study shows the importance to improve the ED working environment as many nurses are burned out, and showed that ED nurses can be burned out and engaged simultaneously. The findings support the Job Demands-Resources Model, and show that enhancing job demands and job resources is important to facilitate engaged ED nurses.Show less
Abstract Young adulthood is the phase of life during which the most alcohol is consumed. This can have negative consequences and long-term effects. These effects might be explained by risk taking...Show moreAbstract Young adulthood is the phase of life during which the most alcohol is consumed. This can have negative consequences and long-term effects. These effects might be explained by risk taking behaviour. The association between risk taking behaviour and alcohol use has already been studied. However, to our knowledge, the relationship between alcohol use and the different domains of risk taking (health/safety, recreational, ethical, social and financial risks) has not been studied. Understanding these different contexts is essential to develop targeted interventions on the relationship between alcohol use and the specific domains to reduce excessive risk behaviours and alcohol use. Therefore, this research studies the extent to which risk taking in different domains is associated with, and predicts, alcohol use in young adults from 18 to 25 years old. The different domains of risk taking are measured by the Domain-Specific Risk Taking questionnaire and alcohol use is measured by the Alcohol Use Disorders Identification Test. This study was conducted cross-sectionally and longitudinally. The cross-sectional part consisted of 89 participants and studies the extent to which there is an association between risk taking in different domains and alcohol use. It is hypothesised that young adults who take risks in different domains also consume more alcohol. From the results, it can be concluded that young adults who consume alcohol are more likely to take health/safety risks, but they are less likely to take social risks. The longitudinal part consisted of 35 participants and studies the extent to which risk taking in different domains predicts alcohol use two years later. It is hypothesised that risk taking in different domains predicts alcohol use two years later. However, results show that risk taking is not predictive of alcohol use two years later. This result could be due to the small sample size of this study. Given these conclusions, it is important to continue with the interventions on health/safety risks and alcohol use and to target new interventions on social risks and alcohol use. In the future, this study could be repeated in other countries with an Eastern culture or in countries with different legal drinking ages.Show less
There is evidence to suggest that child post traumatic symptoms (PTSD) develop within the family system where psychopathology exist. Existing literature indicates that parent and child PTSD are...Show moreThere is evidence to suggest that child post traumatic symptoms (PTSD) develop within the family system where psychopathology exist. Existing literature indicates that parent and child PTSD are associated with each other. The present study aimed to examine the relation between PTSD-symptoms from parents and PTSD-symptoms from their children and whether boys or girls would experience more PTSD-symptoms with a sample of Dutch families (N = 1017). Additionally, it was examined whether quality of life (QoL) would influence this relationship. Mothers, fathers and children completed a questionnaire on trauma symptoms. The same children did also complete a questionnaire on QoL. The PTSD-symptoms from parents and their children were significant related. Furthermore, was there no significant difference between boys or girls in experiencing PTSD-symptoms. The addition of QoL to the relation between PTSD-symptoms from parents and children did not generate a significant result either, the relation became not stronger or weaker. It is possible that there were no significant results due the fact that PTSD is a complex disorder. The relation between PTSD-symptoms from parents and their children is influenced by multiple factors and this may have an impact on the results. It would be beneficial if future research would examine these factors.Show less
In deze scriptie wordt de relatie tussen het eeuwenoude Pyrronistisch Scepticisme en gemoedsrust onderzocht. Aan de hand van Sextus Empiricus worden we meegenomen in de zoektocht naar ataraxia....Show moreIn deze scriptie wordt de relatie tussen het eeuwenoude Pyrronistisch Scepticisme en gemoedsrust onderzocht. Aan de hand van Sextus Empiricus worden we meegenomen in de zoektocht naar ataraxia. Ataraxia oftewel gemoedsrust, is een staat waarin men vrij is van zorgen en angsten. Volgens Sextus is het bereiken van gemoedsrust niet alleen een therapeutische vaardigheid, maar ook een manier van leven. Deze Pyrronistische manier van leven houdt in dat overtuigingen ten aanzien van non-evidente zaken worden opgeschort om zo gemoedsrust te bereiken. In dit onderzoek is onderzocht of de filosofie van het Pyrronisme ons kan helpen in ons dagelijks leven met onze angsten en stress. Om Pyrronisme te meten is er een vragenlijst opgesteld met non-evidente stellingen (NE-Q). Voor het meten van angst is de GAD-7 gebruikt en voor het meten van stress is de PSS gebruikt. De eerste hypothese was dat sterkere overtuigingen een negatieve relatie hebben met gemoedsrust. De tweede hypothese was dat de relatie tussen sterkere overtuigingen en gemoedsrust verzwakt wanneer men aan mindfulness doet. De hoofdrelatie was niet significant met zowel de GAD-7 als de PSS als afhankelijke variabele. Ook was de moderatieanalyse in beider gevallen niet significant. Wel bleek bij verdere visuele inspectie dat het doen van mindfulness leidde tot meer angst en stress, in tegenstelling tot wanneer men niet aan mindfulness deed. Dit onderzoek wijst uit dat de filosofische stroming van het Pyrronisme als psychotherapie niet toepasbaar is voor de behandeling van angsten en stress in de hedendaagse tijd. Ook kan geconcludeerd worden dat mindfulness de relatie tussen het hebben van sterkere overtuigingen en gemoedsrust niet beïnvloedt.Show less
This research explores the interplay between social media usage, offline and online interactions, perceived social support, and depression levels among university students. Analyzing data from 430...Show moreThis research explores the interplay between social media usage, offline and online interactions, perceived social support, and depression levels among university students. Analyzing data from 430 participants, this cross-sectional study leverages the Patient Health Questionnaire-9 (PHQ-9) to assess depression symptoms and employs both multivariate and univariate linear regression analyses, as well as MANOVA and ANOVA tests, to understand the connections between online/offline social interactions, perceived social support, and depression. Key findings indicate a significant relationship between the level of perceived social support (β = -0.49, p < .001) and frequency of online interactions (β = 0.43, p < .05) with depression levels. Notably, individuals reporting higher levels of perceived social support tend to exhibit lower depression levels, while those with frequent online interactions often show higher depression levels. The study also identifies marked gender differences in social media use and depression, with females showing greater susceptibility. These results underscore a nuanced relationship between active/passive social media engagement, gender, and mental health. The research emphasizes the need for mental health strategies that consider individual differences, particularly focusing on the quality of social support and patterns of online engagement, to effectively address mental health concerns in young adults.Show less
In an era marked by escalating environmental challenges and the imperative to address climate change, this study explores the relationship between social mindfulness (SoMi) and environmental...Show moreIn an era marked by escalating environmental challenges and the imperative to address climate change, this study explores the relationship between social mindfulness (SoMi) and environmental concern (EC) on an individual level. It builds on previous research that identified correlations between SoMi and EC at a country level. This study hypothesizes a positive relationship between SoMi and EC, examining this relationship across three facets: attitude, intention, and behavior. Additionally, it investigates the connection between SoMi and concern for future generations. This study consists of a lab study with (N = 108). The results indicate a significant association between SoMi and environmentally concerned intentions, suggesting the significance of promoting social mindfulness to enhance pro- environmental intentions. However, no significant relationship was found between SoMi and EC across the facets of attitude, behavior, or concern for future generations. These non- significant findings align with recent studies emphasizing differences in the relationship between SoMi and EC at country level and individual level. Practical implications of this study include the development of educational programs to promote social mindfulness and enhance pro-environmental intentions. The study highlights the complexities of bridging the gap between intention and behavior in environmental concern and the need for future research to address this challenge comprehensively.Show less
Background: Intensified Prolonged Exposure (iPE) therapy has proven its efficacy in reducing PTSD symptoms. However, its effectiveness in naturalistic settings and underlying mechanisms of action...Show moreBackground: Intensified Prolonged Exposure (iPE) therapy has proven its efficacy in reducing PTSD symptoms. However, its effectiveness in naturalistic settings and underlying mechanisms of action are still under investigation. Objective: The current study investigates the effectiveness of iPE in reducing PTSD symptoms in a naturalistic setting. Additionally, the role of trauma-related maladaptive cognitions in predicting changes in PTSD symptoms was examined, thereby testing the cognitive model of PTSD. Methods: The study is based on anonymous data provided by the LUBEC mental health care facility in Leiden, following the iPE procedure outlined by Oprel et al. (2017). Patients with PTSD received 12 sessions of iPE administered over four weeks and two booster sessions at one-month intervals. Assessment of PTSD symptoms, including maladaptive cognitions, was conducted using the PCL-5 questionnaire at eight measurement time points: before the beginning of the treatment (baseline), during each of the four weeks of active treatment, after the two monthly booster sessions, and three months after the end of the treatment (end evaluation). Results: data of 58 participants was included in the study. The treatment resulted in a large improvement in PTSD symptoms, with 43.1% of the patients showing a clinically significant change in symptoms. Maladaptive trauma-related cognitions significantly decreased throughout the course of treatment. In contrast with expectations, preceding changes in maladaptive cognitions did not predict changes in PCL-5 score, while preceding changes in PCL-5 score predicted later changes in maladaptive cognitions. Conclusion: iPE is effective in reducing PTSD symptoms and maladaptive cognitions in a naturalistic setting. Preceding decrease in PTSD symptoms predicts a decrease in trauma-related cognitions; conversely, changes in cognitions do not impact later PTSD symptoms severity.Show less
