This research was performed to determine which type of model gives a better prediction of the drugs transport into and inside a tumor cell. Two types of models have been developed with compartment...Show moreThis research was performed to determine which type of model gives a better prediction of the drugs transport into and inside a tumor cell. Two types of models have been developed with compartment modeling using the partition coefficient and concentration gradient of a compound. We compared the simulations of these models with varying the drug’s partition coefficient. The model with intermediate steps to cross the membrane takes more time than the model without these steps to reach the partition in equilibrium of the drug in the several compartments. This suggests that the model including these steps give a better prediction of real life drug transport. From a certain value for the partition coefficient, the drug does not enter the cell faster if we increase this value. These results suggest that the model with the intermediate steps is most effective for modeling data for different compounds to test whether they would be suitable drugs to treat cancer.Show less
This paper presents an initial approach to investigate the feasibility of fabricating FSF heterostructures, for potential applications in spintronics. These FSF stacks could help characterize long...Show moreThis paper presents an initial approach to investigate the feasibility of fabricating FSF heterostructures, for potential applications in spintronics. These FSF stacks could help characterize long-range triplet Cooper pairs that are created at its interfaces. Simulations inform the final design of a 3D FSF stack, composed of one low and one high aspect ratio rectangular shape. Subsequent efforts were directed on the focused ion beam milling of apertures in 1 µm thick Si3N4 membranes that are used for shadow evaporation of the heterostructures. Several stacks of cobalt and niobium were fabricated with these membranes through shadow evaporation. These heterostructures were contacted via electron beam lithography and measured in a vectormagnet cryostat. Results indicate that no long-range triplets were generated inside the FSF stacks. It can be concluded that either the niobium layers did not become superconducting or the magnetization of the two ferromagnets in the stacks were not perpendicular.Show less
