Background. The prevalence of metabolic syndrome is high in patients with depression or anxiety, which might explain the higher risk of cardiovascular mortality in this population. Symptoms of...Show moreBackground. The prevalence of metabolic syndrome is high in patients with depression or anxiety, which might explain the higher risk of cardiovascular mortality in this population. Symptoms of affective disorders can lead to changes in eating behaviors. However, poor diet quality seems implicated in underlying pathology of behavioral health disorders and could be a risk factor for developing depression and anxiety disorders. Objective. We aim to investigate the association between diet quality and metabolic syndrome in participants with and without anxiety and depressive disorders. Psychotropic medication, symptom severity, and lifestyle factors (i.e. physical activity, smoking, and alcohol use) are investigated as potential moderators. Methods. In the Netherlands Study of Depression and Anxiety (NESDA), the Mediterranean diet, the metabolic syndrome, physical activity, smoking, alcohol use, severity of symptoms, and medication were assessed among participants with depressive (n = 110), anxiety (n = 149), remitted disorders (n = 761), comorbid disorders (n = 110), and healthy controls (n = 295), in a cross-sectional design. Follow-up data from NESDA wave six is used, nine years after baseline measurement. Results. Participants (n = 1425) were on average 52.4 years old (SD = 13.13) of which 65.2% female. The association between diet quality and metabolic syndrome was the strongest for individuals with current depression (β = -.23 (CI: -.42 ; -.08); t = -2.87; p = .005), comorbid disorders (β = -.20 (CI: -.36 ; -.02); t = -2.22; p = .029), and remitted disorders (β = -.12 (CI: -.19 ; -.06); t = -3.85; p < .001). The association between diet quality and metabolic syndrome was not moderated by medication, symptom severity and lifestyle factors. Limitations. Results cannot be generalized to other cultures and the use of self-report scales could lead to a misclassification bias. Due to the cross-sectional design, it is impossible to provide evidence for temporal or causal relations. Conclusion. Low adherence to the Mediterranean diet is associated with a high score on metabolic syndrome for patients experiencing depression, comorbid depression and anxiety or remitted depression or anxiety. This association is not moderated by medication, symptom severity and lifestyle factors.Show less
