Up to a third of children experience childhood maltreatment (CM), which is abuse and/or neglect by a caregiver. CM is a robust risk factor for depression, and adolescent depressive symptoms seem to...Show moreUp to a third of children experience childhood maltreatment (CM), which is abuse and/or neglect by a caregiver. CM is a robust risk factor for depression, and adolescent depressive symptoms seem to increase during the COVID-19 pandemic. This study therefore investigated whether childhood maltreatment was associated with a further increase in adolescent depression in response to the pandemic, and what role self-esteem and loneliness play in this association. We examined depressive symptoms before (up to March 2020) and during the pandemic (April 2020), in a sample of 79 adolescents (16-26 years old) of which 67.1% were female and non were non-binary (REACT study; Smith et al., 2021). We found that CM was predictive of depression during the pandemic, but not of depression before the pandemic, nor of an increase in depressive symptoms. Furthermore, we found that loneliness was a significant mediator of the relationship between CM and depression during the pandemic, whereas self-esteem was found to be an independent predictor of depression increase. Based on these findings depression prevention/intervention programs are advised to identify CM survivors and to target loneliness and low self-esteem.Show less