This thesis investigates the presence of body language, specifically gestures and facial expression, in the Audio-description for the Dutch film ‘Wat is dan Liefde’ (Webster, 2019). The thesis...Show moreThis thesis investigates the presence of body language, specifically gestures and facial expression, in the Audio-description for the Dutch film ‘Wat is dan Liefde’ (Webster, 2019). The thesis looks at how these elements are described to blind and visually impaired audiences through Audio-description. By using the methodology of Multimodal Transcription, this thesis is able to show the Audio-description and dialogue paired with the relevant image of body language throughout the thesis. The results show that the features of facial expression and gestures are not often described in the Audio-description. The Audio-description features more descriptions of facial expressions than gestures. An explanation for this could be that the gesture is more often included in the dialogue.Show less
The nucleosome core particle is at the lowest level of DNA compaction, a mechanism that enables the DNA to fit inside the cell nucleus. Multiple nucleosomes, connected to each other like beads on a...Show moreThe nucleosome core particle is at the lowest level of DNA compaction, a mechanism that enables the DNA to fit inside the cell nucleus. Multiple nucleosomes, connected to each other like beads on a string, can stack tightly together to form the chromatin fiber. The compact form of this structure hinders external proteins and enzymes from accessing the nucleosomal DNA and using them in fundamental DNA processes. Nucleosome breathing is a process in which access is facilitated by the transient unwrapping of the nucleosome, thereby exposing the otherwise occluded DNA. This thesis investigates the nucleosome breathing mechanism in a dinucleosome system, a sub-structure of the chromatin fiber where two identical nucleosomes with varying DNA sequence are connected by a piece of linker DNA of varying length. The accessibility of the nucleosomal binding sites is modelled through a statistical model, expressing the breathing process in terms of the adsorption energy of the binding sites and the elasticity of the bent DNA in a dinucleosome configuration. The elastic energy of the bent linker DNA and nucleosomal DNA during the breathing process is estimated through a Monte-Carlo simulation. The results make clear that binding sites in such a dinucleosome structure are much more accessible than binding sites in a mononucleosome. Our findings show that the length of the linker DNA and the sequence of the nucleosomes are a determining factor of the dinucleosome configuration, thereby suggesting that these parameters play an important role in regulating the accessibility of higher order structures such as the chromatin fiber.Show less
Research master thesis | Arts and Culture (research) (MA)
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In the last three decades, the world has changed tremendously because of the internet and new digital technologies. This change has affected the way how cultural institutions are working internally...Show moreIn the last three decades, the world has changed tremendously because of the internet and new digital technologies. This change has affected the way how cultural institutions are working internally and also the external interaction with the public. Starting from the 1990s onwards, digital exhibitions have evolved. Digital textile and dress exhibitions are not restricted by time or place and grant broad public access to the collection of institutions. With the case study of the Textile Research Centre (TRC), this thesis shows the benefits and limitations of digital textile and dress exhibitions for opening up access to heritage collections and analyzes its prejudices and barriers. The research is carried out through a literature review, an extensive critical visual analysis and a digital lace exhibition that has been conducted in the frame of this work. The analyzation shows that virtual exhibitions are more accessible when providing a user-friendly layout, quality images of the objects, and the quality of information.Show less
Research master thesis | Arts and Culture (research) (MA)
closed access
This research maps the problems experienced by the prelingual Deaf in museums. Most Deaf people face linguistic, educational, and social barriers in museums. Nowadays, more and more museums make an...Show moreThis research maps the problems experienced by the prelingual Deaf in museums. Most Deaf people face linguistic, educational, and social barriers in museums. Nowadays, more and more museums make an effort to create access to their collection of artworks through programmes designed especially for Deaf people, like guided tours in sign language by Deaf museum educators or on tablets. An inclusive museum, however, is not labelling people as ‘Deaf’ or ‘hearing’, but is accessible to everyone without the need to design special programmes for particular groups. This interdisciplinary research combines Museum Studies, philosophy, Disability Studies, and cognitive neurosciences, to raise awareness for the inaccessibility of museums to the prelingual Deaf, and develops a theory of a multisensory presentation of collections of artworks that is accessible and beneficial not only to the Deaf, but also to other visitors. From the viewpoint of the museum visitor as embodied being, this research examines the possibility to make aesthetic judgments based on touch, taste, and smell.Show less
