This study has investigated the (possibly) mediating role of stress in the relationship between adverse childhood experiences (ACEs) and quality of life (QoL) in adolescents with substance use...Show moreThis study has investigated the (possibly) mediating role of stress in the relationship between adverse childhood experiences (ACEs) and quality of life (QoL) in adolescents with substance use disorder (SUD), whilst correcting for the severity of the addiction. Adolescents are vulnerable to developing SUD and as substance misuse has a neurodegenerative effect, it is important to understand the mechanics behind SUD in adolescents. This current study consisted of 334 adolescents with SUD, with the age ranging from 16 to 23 years old. Cannabis was the primary substance for which participants entered treatment (63.5%), followed by alcohol (17.7%) and cocaine (11.1%). The WHODAS-2.0 was used to measure Qo. To measure self-reported stress the DASS-21 was used, whereas hair cortisol concentration (HCC) was used to measure chronic stress. The YIT-Q was used to measure the ACEs and finally, the MATE-Y was used to measure the SUD severity. HCC is a proposed biomarker for chronic stress. As it is relatively new, HCC has not yet been investigated for adolescents with SUD. Two mediations were investigated, one with HCC as variable for stress, and one with self-reported stress. Study findings showed that the relationship between ACEs and QoL was fully mediated by self-reported stress, whereas no mediation was found for HCC. This indicates a difference in HCC and self-reports as a measure of stress and highlights the importance for continued research into HCC as biomarker for chronic stress. A recommendation for future research is to further investigate the usability of HCC as a biomarker for chronic stress, for example by continuing investigating HCC in adolescents with SUD, as current study was the first to do so. Additionally, it is recommended to repeat the mediation analysis in a broader population to investigate whether HCC does have a mediating role in other populations.Show less
Research master thesis | Psychology (research) (MSc)
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Posttraumatic stress disorder (PTSD) and dissociative symptoms often co-occur. Yet, the symptom interrelations between PTSD and dissociation have not been disentangled. The timing and type of...Show morePosttraumatic stress disorder (PTSD) and dissociative symptoms often co-occur. Yet, the symptom interrelations between PTSD and dissociation have not been disentangled. The timing and type of traumatic events have been suggested to play crucial roles in the comorbidity between PTSD and dissociative symptoms. Therefore, partial correlations between PTSD, dissociative symptoms, and adverse childhood maltreatment (ACE) were investigated in two regularized partial correlation networks. Online self-report responses from participants (N = 495) of an overarching study on domestic violence were used. Symptoms and maltreatment types were assessed with the Post-Traumatic Stress Disorder Checklist DSM-5, the Dissociation Experience Scale-II, and the Childhood Trauma Questionnaire-Short Form. The first network analysis included nine nodes (four PTSD symptoms, three dissociation symptoms, two assumed confounders). The second analysis additionally considered five ACE types. The network exploration revealed few and weak connections between PTSD and dissociation. Regardless of the bridge strength, absorption/imagination and hyperarousal showed to be hubs linking PTSD and dissociative symptoms. Adding ACE barely changed the bridges between PTSD and dissociative symptoms. Amnesia appeared to be a hub for connecting dissociative symptoms to ACE. Emotional abuse was the only maltreatment type connected to the PTSD symptoms. These preliminary findings suggest that PTSD and dissociation are largely independent constructs and hint towards separate diagnostic entities. The study was limited by the sample’s subclinical symptoms and maltreatment scores. This limitation may also be partly responsible for the poorly connected network. Prospective studies with clinical samples are needed to further investigate the interplay between PTSD, dissociation, and ACE.Show less
