The coronavirus (COVID-19) pandemic has been associated with adverse psychological symptoms. Psychotropic prescription drugs are a critical tool in treating and controlling a variety of...Show moreThe coronavirus (COVID-19) pandemic has been associated with adverse psychological symptoms. Psychotropic prescription drugs are a critical tool in treating and controlling a variety of psychopathological conditions, which raises concern in terms of potential overuse and irrational use. Available data regarding the use and prescribing practices of psychotropic prescription drugs during the COVID-19 pandemic are inconsistent. Therefore, a systematic review and meta-analysis was conducted with the aim of investigating the change in psychotropic prescription drug use and dispensing in relation to COVID-19. Pub-med and Web of Science Databases were systematically searched, and a total of 30 studies were included (23 prevalence estimates, and 19 correlation coefficient estimates; total N = 5,133,032). The yielded findings demonstrated a statistically significant increase of 16.34% (95% Confidence Interval [CI]: 9.11 to 23.57) in prevalence estimates of psychotropic prescription drug use. Furthermore, the conducted meta-analysis yielded a small positive statistically significant correlation r = 0.11 (95% CI: 0.05 to 0.16), implying a small increase in psychotropic prescription drug use and dispensing pre relative to post COVID-19. The association between COVID-19 and adverse mental health, as well as the increased use of psychotropic medications, may lead to an upsurge in substance use related disorders and overdose-related deaths. This is important to know, given that many substance use treatment programs during the pandemic have been disrupted. It may be essential for policy makers and health officials to address mental and behavioral health through telemedicine.Show less