Background: Psoriasis is a common chronic skin condition characterized by red plaques, itching, scaling, and thickened skin. Stigma from the general public against people with psoriasis is a...Show moreBackground: Psoriasis is a common chronic skin condition characterized by red plaques, itching, scaling, and thickened skin. Stigma from the general public against people with psoriasis is a prevalent issue. Stigma in psoriasis has been studied mostly from the patient's perspective, while very little research has been done on public stigma from the perspective of the general population. There are several factors that may play a role in the stigmatization of people with psoriasis, such as knowledge, familiarity and empathy. Understanding these factors is crucial for developing effective interventions to tackle stigmatizing attitudes. Aims: the aim of this study was to explore potential factors that are related to stigmatizing attitudes from the general public towards individuals with psoriasis and to investigate how these factors were linked. Methods: This study was a sub-project of a bigger study and had a cross-sectional repeated measures within-subjects design. The sample consisted of 150 respondents from the Dutch population, with an average age of 33 years (SD = 13.1), comprising 48 men and 118 women. The respondents had to read a vignette about an encounter with a man with psoriasis after which we measured stigmatizing attitudes towards this person. The study assessed various factors related to these stigmatizing attitudes, including knowledge, familiarity, and empathy. Results: Less knowledge was associated with higher levels of stigmatizing attitudes (R² = 0.16, F(1, 149) = 29.11 , p < .001), as well as less familiarity with other people that have skin diseases (R² = 0.06, F(1, 149) = 10,04, p = .002). However, these relationships were not mediated by empathy. Discussion: This study highlights the potential significance of knowledge and familiarity in reducing stigmatizing attitudes towards people with psoriasis, suggesting the importance of interventions aimed at increasing public understanding and interactions between individuals with and without psoriasis. While empathy did not mediate the relationship between knowledge, familiarity, and stigmatizing attitudes, it is too early to conclude that empathy is irrelevant. By reviewing other studies, we found that empathy could be examined more extensively in several ways. Therefore, by considering different ways of measuring empathy, we can potentially see its role. Consequently, future research should further investigate and expand the ways in which empathy is assessed.Show less