Research master thesis | Psychology (research) (MSc)
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Adolescence is characterized by the onset of puberty. Puberty, in turn is shown to be a driver of brain development and has been related to the onset and increase of internalizing symptoms. However...Show moreAdolescence is characterized by the onset of puberty. Puberty, in turn is shown to be a driver of brain development and has been related to the onset and increase of internalizing symptoms. However, the relationship between puberty, brain development, and internalizing symptoms has not been studied using multiple pubertal measures in both sexes. Here we examine the mediating role of brain development on the relationship between puberty and internalizing symptoms. Pubertal status, timing, age at menarche, and internalizing symptoms were assessed based on self-reports in 160 adolescents between 10 and 25 using a three-wave accelerated longitudinal design. Structural MRI scans were only obtained in the first wave. Subsequently, the relations between the pubertal measures (status, timing, age at menarche) and internalizing symptoms were tested as well as their relations with grey matter thickness and volume in frontal, cingulate, and subcortical areas. Only age at menarche as a timing variable had a significant effect on internalizing symptoms at T1 in girls (ß = -.36, p = .002, 95% CI [-.68, -.17]). Mediation models revealed no significant mediation of grey matter thickness and volume in our ROIs. Other effects did not reach significance or became non-significant after Bonferroni corrections. These findings indicate that menstruating before one’s peers is a risk factor for developing internalizing symptoms. This highlights the importance of supporting early menstruating girls to possibly prevent them from developing internalizing symptoms. Replication studies are needed to assess the accuracy of our results.Show less
