Background: Humans seem to be increasingly disconnected from nature and from themselves, which appears to be essentially linked to mental illnesses and lower levels of well-being. However, current...Show moreBackground: Humans seem to be increasingly disconnected from nature and from themselves, which appears to be essentially linked to mental illnesses and lower levels of well-being. However, current literature reveals promising results for psychedelic interventions. Previous research findings suggest that nature relatedness and feelings of connectedness increase via psychedelic experiences, and that natural trip settings might amplify these relationships even more. Methods: Using linear regression analysis, moderation and mediation analysis we investigated the association between trip setting and nature relatedness and connectedness among psychedelic drug users (N=190) in a cross-sectional online survey. For exploratory purposes we investigated the effect of predominant living environments. Results: More naturalistic settings were positively associated with increases in nature relatedness and connectedness. Naturalistic living environments did not predict nature relatedness. Connectedness mediated the relationship between trip setting and nature relatedness. Conclusion: The present study provides evidence for a correlational effect of naturalistic environment during psychedelic use on increases in nature relatedness and connectedness, which appears of great relevance for the field of mental health and treatments using psychedelics.Show less