Children with sex chromosome trisomy (SCT) are at increased risk for psychopathology, particularly within the social domain. This study investigates whether children with SCT exhibit elevated...Show moreChildren with sex chromosome trisomy (SCT) are at increased risk for psychopathology, particularly within the social domain. This study investigates whether children with SCT exhibit elevated autism traits compared to typically developing children, given the difficulties in social interaction and communication that are typical of autism spectrum disorders. The sample comprised 67 children with SCT (27 girls with XXX, 29 boys with XXY, 11 boys with XYY) and 70 typically developing children, aged 2.5 to 7.5 years. Autism traits were assessed using the Social Responsiveness Scale, Second edition (SRS-2). Statistical analyses revealed that children with SCT demonstrate more severe deficits in social responsiveness than typically developing children, scoring primarily in the subclinical range. Children with SCT scored significantly higher on all assessed autism aspects, with social awareness being the least affected compared to the control group. No differences were found across different karyotypes, suggesting a consistent elevation of autism traits across SCT genetic variants. Age had no effect on the severity of autism traits, implying stability across development. These insights enhance understanding of the specific needs and challenges of children with SCT in their social development, which is crucial for the development of effective support and intervention programs. Additionally, these findings underscore the importance of early detection and intervention for children with SCT, with autism traits serving as potential early indicators of SCT presence.Show less
Research master thesis | Psychology (research) (MSc)
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Having an extra sex chromosome is known as sex chromosome trisomy (SCT). This may result in 47,XXY, 47,XXX, or 47,XYY. Previous research suggested that social attention to the eyes is reduced in ...Show moreHaving an extra sex chromosome is known as sex chromosome trisomy (SCT). This may result in 47,XXY, 47,XXX, or 47,XYY. Previous research suggested that social attention to the eyes is reduced in (young) adults with SCT and that individuals with SCT have more autistic characteristics compared to typically developing (TD) controls. It was unknown whether the group differences were also present in early childhood. The current study aimed to explore social attention, autistic traits, and their relation in three subgroups of children with SCT (47,XXY, 47,XXX, and 47,XYY; N = 70), aged 3 to 7 years, in comparison to TD peers (N = 62). Social attention to the eyes was measured using three eye-tracking video paradigms: A single-face condition, a multiple-face condition and a social interaction condition. Autistic traits were measured using the Social Responsiveness Scale-Second Edition. Results showed a difference in social attention between children with SCT and TD children during the social interaction condition. There was no difference in social attention between the SCT subgroups. The SCT group showed more autistic traits than the TD group and the 47,XXX subgroup had more autistic traits than the 47,XXY subgroup. There was a significant relation between social attention during the single-face condition and autistic traits in the 47,XYY subgroup only. Implications of these findings are discussed in relation to the importance of monitoring socio-cognitive challenges related to SCT in early childhood.Show less
