Research master thesis | Developmental Psychopathology in Education and Child Studies (research) (MSc)
open access
2020-04-25T00:00:00Z
Objective: Poor emotion regulation in early development has been related to negative child outcomes and is expected to be influenced by interactions with primary caregivers. This study examines the...Show moreObjective: Poor emotion regulation in early development has been related to negative child outcomes and is expected to be influenced by interactions with primary caregivers. This study examines the relation between infant emotion regulation and maternal self-regulation. Method: The sample consisted of 132 infant-mother dyads. Maternal emotion regulation (ER) problems and executive functioning (EF) problems were assessed during pregnancy by means of the Difficulties in Emotion Regulation Scale and the Behavioral Rating Inventory of Executive Function—Adult version. At six months of age, infant’s behavioral and physiological stress responses were observed during the Still Face Paradigm (SFP). Results: In response to the still face, infants showed an increase in heart rate and negative affect, and a decrease in positive affect and gaze. Infants of mothers with more ER problems showed more reactivity on heart rate, and arching and squirming. During the still face, infant self-soothing behavior increased. In response to the reunion positive affect, gaze, self-soothing behavior and negative affect increased, while arching and squirming behavior decreased. Infants of mothers with more ER problems, but few EF problems, showed less gaze during the still face, and higher levels of negative affect in general. Conclusion: This study underlines that a mother’s capacities to self-regulate influence the infant’s stress system and the emotional development of their infant. Helping mothers to enhance their own ER capacities could possibly decrease the risk for future psychopathology for their infants.Show less
Research master thesis | Developmental Psychopathology in Education and Child Studies (research) (MSc)
open access
2016-12-16T00:00:00Z
This study investigated an aspect of cognitive functioning or more specifically of executive functioning, that appears to be strongly affected in NF1: working memory. The primary goal of this...Show moreThis study investigated an aspect of cognitive functioning or more specifically of executive functioning, that appears to be strongly affected in NF1: working memory. The primary goal of this functional MRI study was to investigate whether or not the neuronal activity during working memory performance differs between NF1 children and controls. A second aim was to investigate the working memory performance outside the scanner. Participants included children with NF1 (N=21, 7 female), and controls (N=18, 10 female). Ages ranged between 8.2 and 19.1 (Mage= 13.12, SD=3.17). Neuronal activity was measured during the N-back task, and working memory performance outside the scanner was measured with the Memory Search 2D task of the ANT program. With respect to the main aim, the group means comparisons revealed non-significant differences. Though, the participants with NF1 had greater activity in the prefrontal cortex, and less activation in the posterior brain regions compared with controls. Overall, the NF1 children performed poorer on the working memory task outside the scanner. They performed even worse on the second, more demanding condition than the controls. These results may be explained by the dysfunction of the protein neurofibromin and a possible compensatory function of brain regions in individuals with NF1. These insights in brain functioning of individuals with NF1 might contribute to the development of intervention or treatment programs, medication and gene therapy.Show less
Research master thesis | Developmental Psychopathology in Education and Child Studies (research) (MSc)
open access
2016-10-29T00:00:00Z
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder associated with multiple cutaneous, physical and neurological symptoms. The aim of this study was to validate current NF1...Show moreNeurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder associated with multiple cutaneous, physical and neurological symptoms. The aim of this study was to validate current NF1 severity scales using PCA, and relating the NF1 severity scale and components to cognitive and behavioural outcomes. Participants were 18 children diagnosed with NF1 aged 8 to 16 years. The PCA showed that NF1 symptoms could be divided into neurological and appearance symptoms. The presence of more neurological symptoms was associated with a lower score on the task Comprehension. More symptoms in the appearance were associated with less assertiveness. A higher total number of NF1 symptoms was negatively related to the scale meta-cognition of the BRIEF, indicating poorer executive functioning in daily life for children with more NF1 symptoms. Also, elevated autistic traits were observed using the SRS, and poorer emotion recognition as measured with the ANT. Together, these results might indicate that children with NF1 share a neuropsychological profile commonly seen in children with ASD, which might be related to neurological symptoms.Show less
