Statistical matching is a technique which can be applied when one wants to investigate the joint relationship between two variables that are observed in different datasets, using one or more...Show moreStatistical matching is a technique which can be applied when one wants to investigate the joint relationship between two variables that are observed in different datasets, using one or more variables that overlap in both datasets. This joint relationship cannot be estimated without relying on assumptions or additional data. Classically, statistical matching is based on the Conditional Independence Assumption (CIA) which asserts the non-overlapping variables to be independent given the overlapping variable. This assumption is inflexible, untestable and often does not hold. The current project proposes to use an approach based on the Instrumental Variable Assumption (IVA). An instrumental variable is a variable that, given the value of some mediating variable, has no effect on some outcome variable. In the context of statistical matching this gives rise to three scenarios: the mediating variable overlaps, the outcome variable overlaps, or the instrumental variable overlaps. The IVA approach is more flexible than the CIA approach. This is because the IVA approach does not make any assumptions on which variable is the overlapping variable, whereas the CIA always conditions on the overlapping variable. The aims of the current study were twofold: 1) how does the IVA approach perform when the assumption is violated to various degrees and 2) how does the IVA approach compare to the CIA approach. To answer these questions, a simulation study was performed. For each scenario, joint probabilities of the non-overlapping variables were estimated under both the IVA and the CIA in populations which violate the IVA to various degrees. Measures for the bias, accuracy and precision were estimated and compared. The results indicate that the IVA approach is moderately robust against slight violations of the assumption. When the IVA is not violated, estimations are unbiased and for all matching scenarios the method outperforms the CIA. When the IVA is violated it is advisable to rely on the CIA, since results of the current simulation study suggest the CIA to be more robust against violations in general.Show less
In dit onderzoek wordt het effect van de mate van het vertrouwen in de overheid op verschillende burgerparticipatievormen onderzocht. Uit het onderzoek blijkt dat er een sterk positief effect is...Show moreIn dit onderzoek wordt het effect van de mate van het vertrouwen in de overheid op verschillende burgerparticipatievormen onderzocht. Uit het onderzoek blijkt dat er een sterk positief effect is van het vertrouwen in de overheid op het stemmen tijdens nationale en lokale verkiezingen. Met betrekking tot het meedoen aan demonstraties en het ondertekenen van petities is er geen duidelijk effect zichtbaar.Show less
This study analyses the role of issue saliency in the relationship between the retrenchment of the welfare state and the electoral outcomes of government parties in the next election. The role of...Show moreThis study analyses the role of issue saliency in the relationship between the retrenchment of the welfare state and the electoral outcomes of government parties in the next election. The role of issue saliency is tested by a statistical analysis across 25 European countries between 2001-2021. Three welfare state indicators, healthcare, pensions and unemployment, are used to see if their effect on electoral outcomes changes when they are more or less salient. The analysis shows a correlation between issue saliency and a positive effect of retrenchment on electoral outcome. Situations of budget constraints can explain the positive effects of electoral outcomes on electoral outcomes. We conclude that issue saliency is an accelerator for the effect the welfare state has on electoral results. Furthermore, we can conclude that budget constraints are an explanatory factor in why retrenchment measures positively affect electoral outcomes.Show less
This thesis investigates the daily life of an early medieval community in Central Italy by focusing on the skeletal collection (n = 66) from the ancient site of Satricum dating between the 9th and...Show moreThis thesis investigates the daily life of an early medieval community in Central Italy by focusing on the skeletal collection (n = 66) from the ancient site of Satricum dating between the 9th and 11th century AD, to advance our understanding of this everchanging period. The research employs the study of paleopathology, with a focus on osteoarthritis (OA), osteochondritis dissecans (OD), and periosteal new bone growth (PNB). The skeletal analyses revealed a high prevalence of joint degeneration, particularly in the spine, hip, shoulder, and elbow, while also PNB was recorded in relatively high numbers. The findings suggest that Satricum was a small, self-reliant community engaged in agricultural practices with ongoing physiological stressors. However, the presence of OA might have been influenced by both activity and genetic predisposition due to the long duration of the community settling in Satricum. The study also explored the impact of sex and age. The osteological assessment indicated a potential surplus of males, aligning with demographic patterns of early medieval times, while the identified females showed no distinctive activity markers, prompting further investigation into the "missing women" concept of the Middle Ages. The presence of only five subadults also raised questions about community beliefs, suggesting a potential societal distinction for individuals under the age of seven since no social separation was recognized between the adults and juveniles over that age. Furthermore, the funerary practices exhibited potential indicators of a Christian belief system, such as burial orientation and the absence of grave goods. The reuse of a Roman villa with a possible apsis also hinted at the presence of an ecclesial building. Comparisons with other Central Italian sites of the same period (Albano, Santa Severa, and Colonna) highlighted pathological and demographic commonalities. Therefore, in the broader context, this research contributes to existing knowledge by confirming scholar’s theories about life in rural medieval Central Italy. Finally, this study emphasizes the significance of investigating previously unstudied skeletal collections because these findings not only deepen our understanding of Satricum but also provide a foundation for future research, encouraging diverse approaches to further unravel the complexities of this ancient community.Show less
Since the formation of the contemporary Northern-Spanish autonomic community of Cantabria in 1981 the Iron Age has become increasingly important for its regional identity, symbolically embedded in,...Show moreSince the formation of the contemporary Northern-Spanish autonomic community of Cantabria in 1981 the Iron Age has become increasingly important for its regional identity, symbolically embedded in, for example, its name and flag. Although this in itself can be viewed as problematic, it also fuelled more archaeological investigations into Iron Age Cantabria. These investigations have mainly been focused on Iron Age hillforts of which currently approximately fourty-three (43) can be found throughout the autonomic community. The relatively late development of this field of study is one of the reasons why this number is significantly lower than the other northern Spanish autonomic communities of Asturias and Galicia. Simultaneously, Eucalyptus plantations have become the dominant form of forestation covering approximately 8% of total ground surface and forming 19% of the total amount of forests in Cantabria. This vegetation cover is found predominantly in the coastal region, where few of the identified Iron Age hillforts are found and where the plantations encroach on identified hillforts, making identification of new hillforts more difficult. While new digital tools and data for cultural resource management have become available, such as Light Detection and Ranging (LiDAR) and Geographic Information Systems (GIS), their usage have been limited in this region. To address this issue the research poses the question: ‘How can available methods and tools of archaeological prospection and cultural heritage management be used in an integrated workflow to find, map and preserve Iron Age hillforts under Eucalyptus plantations in Cantabria?’. The proposed integrated workflow consists of narrowing down suitable locations for Iron Age hillforts through object-based predictive modelling (OBPM) and subsequently remote prospection of those locations to identify potential features associated with archaeological sites. To test this approach it has been put into practice. The proposed workflow proved effective, but has also shown limitations. The parameters chosen are most-likely not solely relevant for Iron Age hillforts, consisting out of Geomorophon, incoming visibility-index and out-going visibility index. Also the research focus on Eucalyptus plantations showed a variability of noise in the Digital Elevation Model (DEM) for locations under Eucalyptus plantations, sometimes impeding readability of those areas. Nevertheless, the use of Sky View Factor (SVF) and the sufficiently narrowed down study area still proved effective in finding and documenting possible archaeological features, of which fifty (50) different locations have been identified with a variation of characteristics, all adhering to the set parameters. This suggests that the proposed integrated workflow is currently an effective tool in the finding, mapping and preserving archaeological sites near or encroached by Eucalyptus plantations.Show less
Social media has become an integral component of public agencies and digital diplomacy. Prior scholars have emphasised the significance of social media in International relations (IR), discussing...Show moreSocial media has become an integral component of public agencies and digital diplomacy. Prior scholars have emphasised the significance of social media in International relations (IR), discussing its advantages and difficulties. Nevertheless, in terms of public administration, there is a gap in their management, namely, in understanding how to use different platforms and the significance of social media content in engaging with the public. This research delves into the field of digital Diplomacy, examining the strategic use of social media content by the European Union’s diplomatic missions based in Athens, focusing on engagement with the public. The mixed-method study examined how diplomatic missions use social media content to engage with the public by analyzing original posts on Twitter/X and Facebook and conducting semi-structured interviews with experts and diplomats from EU Ministries of Foreign Affairs (MFAs) and embassies. The findings revealed that the EU embassies tend to employ posts that promote the countries’ image and interests’ indicators of Symbolic representation. In addition,they demonstrate a preference for Transparency by regularly sharing content that aligns with the policies, daily agenda and activity of the MFAs or embassies. The analysis using the Engagement Index (EI) results is noteworthy as it signifies an enhanced public connection with Coproduction content. Finally, the study reveals the strategic use of the platforms and the content for effective public engagement. Future researchers can delve into new directions by exploring other platforms or focusing on public reaction via sentimental analysis. In summary, this research emphasizes the importance of social media in diplomatic missions' external communication and advances the field by implementing the framework in digital diplomacy, particularly in the EU.Show less
The behavioral theory of the firm lacks a comprehensive understanding of issue prioritization, particularly when multiple issues are performing below aspiration levels, or resources are limited....Show moreThe behavioral theory of the firm lacks a comprehensive understanding of issue prioritization, particularly when multiple issues are performing below aspiration levels, or resources are limited. This study investigates the prioritization of eGovernment initiatives, considering budget constraints and the emphasis on historical versus social aspiration levels. Two theoretical expectations were developed: 1) the prioritization of historical versus social aspiration levels, and 2) the prioritization of eGovernment initiatives under budget constraints. Semi-structured interviews with 9 public officials from the Directorate-General for Economic Activities in Portugal were conducted to assess the expectations. The thematic analysis revealed that public officials do not change the priorities of eGovernment initiatives based on budget constraints and predominantly prioritize social aspirations over historical ones. This study highlights the importance of pragmatism driven by necessity alongside creativity. The findings have implications for issue prioritization, performance feedback, cutback management, and public administration literature in general. Future research should expand the study to include coercive aspiration levels, less salient issues, different countries, and different public organizations. Additionally, preferences and public sector motivation can be included as moderators, and employing a mixed-methods approach could be beneficial.Show less
Recent crises have brought asylum-migration to the forefront of political debate in Europe. There has been significant discourse in academic and policymaking spheres concerning migratory pull...Show moreRecent crises have brought asylum-migration to the forefront of political debate in Europe. There has been significant discourse in academic and policymaking spheres concerning migratory pull factors; in particular whether prospective socio-economic entitlements in destination countries are determinants of asylum applicants’ destination choice. Employment rights feature prominently in these discourses, yet few studies directly examine the relationship between labour market access and asylum inflows. This paper exploits Ireland’s transposition of the Recast Reception Conditions Directive in 2018, which ended a comprehensive ban on asylum applicants’ access to the labour market, in order to study the effects of labour market access on the magnitude and demographic composition of asylum applications. Using difference in difference and regression discontinuity methodologies, this paper finds that the labour market access reform caused an increase in the number of asylum applications and in the proportion of working-age applicants in Ireland. These findings contribute to a small body of quasi-experimental literature on the determinants of asylum inflows to destination countries.Show less
De opkomst van protesten, demonstraties en proteststemmen in Europa als gevolg van groeiende onvrede, wantrouwen en een gevoel niet gehoord te woorden door ‘de politieke’ en/of ‘de overheid’ raken...Show moreDe opkomst van protesten, demonstraties en proteststemmen in Europa als gevolg van groeiende onvrede, wantrouwen en een gevoel niet gehoord te woorden door ‘de politieke’ en/of ‘de overheid’ raken aan het fundament waar democratie als politiek- bestuurlijk systeem op is gebaseerd. Een democratie bestaat immers in ieder geval uit volkssoevereiniteit en meerderheidsheerschappij. Responsiviteit maakt hier een essentieel onderdeel van uit aangezien dit gaat over de mate waarin het handelen van de overheid, zoals vastgelegd in beleid en wet-en regelgeving, in overeenstemming is met de wil van het volk. Hoewel er veel onderzoek bestaat naar (overheids)responsiviteit en diens werking aan de ene kant en onderzoek naar politieke partijen en diens (electorale) werking aan de andere kant, is er geen recent en gedegen onderzoek dat deze twee min of meer gescheiden onderzoekvelden in de Europese context combineert. Dit onderzoek kijkt daarom als een van de eerste, aan de hand van een grote steekproef van Europese landen en een focus op herverdeling als concreet beleidsissue, naar de (mediërende) rol die politieke partijen spelen in de link tussen publieke opinie en (overheids)beleid via de centrale onderzoeksvraag: wat is het effect van voorkeuren van burgers ten aanzien van herverdeling op het daadwerkelijk gevoerde beleid van nationale overheden ten aanzien van herverdeling en in welke mate verloopt dit effect via de standpunten van politieke partijen ten aanzien van herverdeling? Door middel van Granger causaliteit in SPSS wordt een unieke dataset, bestaande uit data van de ESS, CHES, OECD en WDI, geanalyseerd. Uit het onderzoek blijkt, tegen de verwachtingen in, dat de voorkeur van burgers ten aanzien van herverdeling geen effect heeft op het daadwerkelijk gevoerde beleid van nationale overheden ten aanzien van herverdeling en dat dit effect niet verloopt via de stadpunten van politieke partijen ten aanzien van herverdeling. Deze onverwachte uitkomst roepen veel vragen op die het uitgangspunt zouden kunnen zijn voor toekomstig onderzoek.Show less
What is the effect of AI technology usage by bureaucrats under problematic conditions on the perceived legitimacy of bureaucratic decisions? Scholars argue that AI usage potentially exacerbates the...Show moreWhat is the effect of AI technology usage by bureaucrats under problematic conditions on the perceived legitimacy of bureaucratic decisions? Scholars argue that AI usage potentially exacerbates the negative consequences of misused bureaucratic discretion. Others suggest that AI usage might curtail bureaucratic discretion and increase outcomes of equity and efficiency. Existing empirical research demonstrates no significant difference between the perceived legitimacy of AI-assisted and human decision-making. This study aims to determine the effect of AI usage on the perceived legitimacy of bureaucratic decisions made under problematic principal-agent dilemma conditions. This effect is assessed across 96 survey respondents from the University of Leiden and the University of Amsterdam using experimental factorial survey analysis. The results of this research indicate that AI usage in decision-making has a significant positive effect on perceived legitimacy (p < 0.001). The main implication of this research is that AI usage can plausibly alleviate the impact of consequential bureaucratic decisions on perceived legitimacy by obscuring bureaucratic discretion. A second implication is that AI usage in bureaucratic decision-making exerts a notable effect on the perceived efficiency of bureaucratic decisions.Show less
Prediction models play a paramount role in various fields such as psychology and medicine, where the aim is to maximize predictive performance while ensuring high interpretability and stability....Show morePrediction models play a paramount role in various fields such as psychology and medicine, where the aim is to maximize predictive performance while ensuring high interpretability and stability. Prediction rule ensembles are a recent statistical learning method that address the black-box problem from common machine learning methods. First, an ensemble of trees is fitted, and by employing sparse regression, such as the lasso, only a subset of those trees is retained in the final ensemble, enhancing interpretability. However, the lasso suffers from drawbacks, considering that the optimal penalty parameter for variable selection may lead to an over-shrinkage of large coefficients. This study investigates if accuracy, sparsity, and stability of prediction rule ensembles can be improved by using the adaptive or relaxed lasso, or their combination. In the adaptive lasso, weight parameters are assigned to each coefficient in the penalty term, while in the relaxed lasso the lasso coefficients are debiased towards unpenalized values. In addition, in this study we compared if the results differ if the model selection was based on the lambda- 1se or lambda-min criterion and between continuous and binary outcomes. For this, the models were evaluated on nine benchmark datasets using repeated 10-fold cross-validation. The results show that all lasso variations improve model sparsity significantly while maintaining high accuracy, but at the cost of stability. The relaxed and adaptive lasso select sparser models than the standard lasso while achieving good stability of variable selection, but at the cost of less stable predictions. The relaxed adaptive lasso yields the sparsest model, but is the most unstable. Regarding lambda criterion, for continuous outcomes the lambda-minimum criterion leads to highly unstable results and diminishes the effect of lasso approach used. For binary outcomes, the lambda-1se criterion only improves accuracy and sparsity, but not stability, while for continuous outcomes it improves all performance diagnostics.Show less
Százhalombatta-Földvár is one of the biggest and most extensively studied Bronze Age tell sites in Hungary. Due to its location on a dry loessy high bluff zone on the Western bank of the river...Show moreSzázhalombatta-Földvár is one of the biggest and most extensively studied Bronze Age tell sites in Hungary. Due to its location on a dry loessy high bluff zone on the Western bank of the river Danube, a sedimentary environment that is appropriate for pollen preservation to conduct pollen analysis was not found around the site (Sumegi & Bodor, 2000). Instead, regional pollen analysis has been conducted to study the environment relating to the Százhalombatta-Földvár site. This regional sediment sample was obtained by coring from an oxbow lake about 500 m away from the site. During the Százhalombatta-Földvár excavation in 2022, however, the lithological examination of the floor sediment from [House] 9000 indicated the possibility for pollen preservation, followed by palynological investigation including the comparison to the regional pollen record. This unconventional method of pollen analysis was successfully conducted, yielding a well-preserved pollen assemblage. The methods of pollen analysis applied are pollen counts, taxonomic identification and states of preservation analysis. These methods indicate that the well-preserved pollen assemblage obtained from the unconventional context does not reflect the pollen assemblage from the oxbow lake pollen record. Especially the absence of arboreal pollen at the site compared to that recorded in the regional pollen data is conspicuous. These results allow us to discuss and investigate the sample from [House] 9000. Specifically, in the sample, taphonomic agents contributing to the absence of arboreal pollen in contrast with the regional palynological signal are analysed and the predominance of Poaceae is explained with taphonomic processes. Furthermore, the taphonomic agents causing the primary pollen preservation states are investigated and the taphonomic processes resulting in the preservation biases are explored in archaeological interpretation. In consequence, the investigation of the taphonomic processes suggests anthropogenic agents causing the discrepancy and bias in the pollen assemblage with the construction and materials used for [House] 9000. The pollen preservation state analysis revealed that the primary states of pollen preservation are degraded and folded. These in turn are evidence of the taphonomic processes of oxidisation and physical stress, which in combination with archaeological evidence suggests anthropogenic activities as cause. To conclude, this thesis could contribute to multi-disciplinary research and greater understanding of the Bronze Age site, Százhalombatta-Földvár. Moreover, it demonstrates new potential of palynological analysis employing an innovative sampling method that directly relates to the human activities at the site. The results of this thesis have the potential to stimulate further application of this new approach.Show less
Tegenwoordig worden ambtenaren geconfronteerd met een intrigerende paradox: enerzijds wordt van hen verwacht dat ze ambtelijke neutraliteit en neutrale bureaucratische competenties bezitten,...Show moreTegenwoordig worden ambtenaren geconfronteerd met een intrigerende paradox: enerzijds wordt van hen verwacht dat ze ambtelijke neutraliteit en neutrale bureaucratische competenties bezitten, anderzijds neemt de druk toe om politiek sensitief en responsief te zijn. Deze paradox weerspiegelt een verschuiving in de rol van ambtenaren, waarbij zij steeds meer dienen als instrument voor de bewindspersoon in diens politieke ambities. De ambtenaar in kwestie balanceert tussen traditionele bureaucratische normen verweven in het ministeriële bestel en de loyale uitvoering van de wil van verkozen politici, waarbij de ambtenaar zich in politieke aangelegenheden mengt. Dit onderzoek richt zich op de ambtenaren die zich bezighouden met overheidscommunicatie via de sociale media van bewindspersonen op Nederlandse ministeries. Er wordt onderzocht in welke mate functionele politisering van hun werkzaamheden plaatsvindt en wat dit veroorzaakt.Show less
In scientific research, interpretability and high predictive performance are difficult to combine: while black-box models perform better than interpretable models, only the latter allow for...Show moreIn scientific research, interpretability and high predictive performance are difficult to combine: while black-box models perform better than interpretable models, only the latter allow for transparency and inference, which are necessary tools when these models are used in decision-making or in hypothesis testing. Models such as RuleFit combine the flexibility of a black-box tree ensemble with the interpretability of a sparse, LASSO linear regression. Later work substitutes Bayesian regression for the LASSO regression, thus further improving the model’s prediction (Horserule). The work in this thesis was two-sided: on the one hand, we applied a different Bayesian prior (the informative Horseshoe prior) to the linear step of the RuleFit model, which can naturally take the structure of RuleFit into account. On the other hand, we used Shapley values to measure the contribution of each predictor in the RuleFit model and combined these values with the Bayesian regression to build inferential tools. The new machinery was tested on both synthetic data and the dataset from the Helius study. The predictive performance of the resulting model was observed to be higher than that of the original RuleFit model, but lower than that of Horserule. Compared to Horserule, the proposed model excessively favours trees over linearity, but in doing so it more strongly enforces the choice of simpler trees. Shapley values were also compared to other importance measures mentioned in the RuleFit literature, and shown to be more accurate in reconstructing the contributions as defined in the synthetic datasets.Show less
This thesis examines a new way of tracing individual life histories in the context of slavery in the Caribbean during the colonial period. The carbon stable isotopes in bioapatite were compared to...Show moreThis thesis examines a new way of tracing individual life histories in the context of slavery in the Caribbean during the colonial period. The carbon stable isotopes in bioapatite were compared to carbon and nitrogen stable isotopes in collagen of serial dentine samples in the case study of an enslaved African found on the island of Saba. Five dental elements were found out of anatomical context in a lockbox at Spring Bay Flat plantation. The use of bioapatite and collagen in tandem has been proved to provide extra valuable information in dietary studies and doing so in dentine increments yields an individual and high temporal resolution new to bioarchaeology. The individual studied here forcibly migrated from the African Sahel during the formation of the first molar, suffering from a period of nutritional stress before experiencing a dramatic dietary change. Multi-isotope analysis of both organic and inorganic matrixes in dentine increments is proven to be a valuable and innovative method of reconstructing individual life histories in unprecedented detail. The production of osteobiographies such as this one helps us to understand individual experiences during periods of slavery, captivity, and exploitation on a level that we can empathise with and therefore offers important and profound contributions to discussions on slavery and colonialism in a broader sense.Show less
The origin of speech is one of the biggest unanswered questions in the evolution of mankind. Scientist from all over the world from different disciplines using different methodologies have been...Show moreThe origin of speech is one of the biggest unanswered questions in the evolution of mankind. Scientist from all over the world from different disciplines using different methodologies have been trying to solve the mystery that is the origin of speech. An unambiguous answer however, remains absent. Using the method of comparative morphology and microbiomechanical studies, it can be studied when in our evolutionary history the anatomy fit to support speech production first arose, and thus which species first had the ability to talk. This thesis looks at published data on different hard structures of the vocal tract, in particular the hyoid, hard palate and mandible, of Australopithecus afarensis, Homo erectus, the SH hominins and Homo neanderthalensis to compare them to those of the modern human and non-human great apes vocal tract, in order to discover what we can infer about the origin speech based on the evolution of the vocal tract. This comparison has shown that based on their features, these hominins can be divided into two categories. The first category is that of archaic morphology and is characterized by a hyoid, hard palate and mandible that most closely resembles the anatomical features of the non-human great apes, in particular, chimpanzees. This means they possessed a bullashaped hyoid body, a long and broad hard palate and a long and narrow, chinless mandible. To this group belong the Australopithecus afarensis and Homo erectus. The second category is that of modern morphology and is characterized by the hyoid, hard palate and mandible that most closely resembles the anatomical features of modern humans. This means a bar-like hyoid body, a shorter and more narrow hard palate and a short and broad mandible with a bony protuberance, the chin. To this groups belongs the SH hominins the Homo neanderthalensis. Based on the results, it can be concluded that the anatomical features of the vocal tract fit to support the production of speech were already in place with, at least, Neanderthals. Therefore, Neanderthals could speak. The way forward for future studies into the origin of speech mainly is more data, both in terms of quantity and more species, though this is not something that can be forced. Establishing the origin of speech might open up a new path into studying the origin of language, a related, but not identical topic.Show less
Research master thesis | Archaeology (research) (MA/MSc)
under embargo until 2024-10-19
2024-10-19T00:00:00Z
During the early modern period (1500-1800 CE), Europe was plagued by syphilis, a venereal infection caused by the bacteria Treponema pallidum, resulting in chronic and debilitating symptoms....Show moreDuring the early modern period (1500-1800 CE), Europe was plagued by syphilis, a venereal infection caused by the bacteria Treponema pallidum, resulting in chronic and debilitating symptoms. Desperate to resolve the infection, patients were often subjected to prolonged and extensive treatments with toxic mercury. Unfortunately, osteoarchaeological study of syphilis is challenging due to the limited skeletal visibility of the infection. Moreover, historical evidence is sparse and often influenced by sociocultural stigma attributed to the venereal nature of the disease. This scarcity of data on syphilis in the early modern period has limited more holistic research into the disease and its treatment. Therefore, this study adopted a multidisciplinary approach to investigate syphilis and its treatment at St. Gertrude’s infirmary (1382 - ca. 1611) in Kampen, the Netherlands, where presence of the disease has been previously reported. Human skeletal remains (n=79) were re-examined with a focus on treponemal disease, following the scoring system laid out by Harper et al. (2011). The potential therapeutical use of mercury was investigated by conducting archival research and multiple trace elemental analyses. Using portable X-Ray Fluorescence Spectrometry (pXRF) and Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), subsamples of the skeletal assemblage were assessed on the presence of mercury in human bone. Scanning Electron Microscopy with Energy Dispersive X-Ray (SEM-EDX) was conducted to assess the potential uptake of mercury in dental calculus on the teeth. Osteoarchaeological study identified several diagnostic cases of treponemal infection at the site (n=5 or 6.33%), as well as a number of cases with lesions suggestive of treponemal disease. This finding demonstrates the influence of treponemal disease, likely attributable to venereal syphilis, at St. Gertrude’s infirmary in Kampen, especially when compared to the prevalence of the disease in human skeletal assemblages from similar Dutch sites. Research into historical archives indicated that mercury was indeed used therapeutically in Kampen during the 18th century. However, it showed no direct evidence for syphilis or mercury treatment at St. Gertrude’s infirmary in the period of interest (1382 – ca. 1611). Unfortunately, elemental analyses revealed no substantial evidence for significantly elevated mercury concentrations, although interesting trends were found. In particular, both pXRF and SEM-EDX analyses did not result in absolute and quantifiable mercury concentrations. While ICP-MS analysis showed absolute concentrations of mercury in a subsample of bone material, interpreting and contextualising these results remains challenging. These observations may be explained by a lack of available mercury treatment in Kampen or a preference for other treatment methods. Nonetheless, this study helps to understand syphilis and its treatment in the early modern Netherlands and provides an evaluation of chemical analyses to detect mercury in archaeological bone.Show less
