Computer Modeling of Thymic Epithelial Cell Morphology

Many types of cells in the body exhibit intricate shapes, often characterized by elongated projections that are essential for their function. Nerve cells are a prime example, but even immune cells such as thymic epithelial cells (TECs) in the thymus rely on these dynamic structures. TECs are large cells that play a crucial role in the maturation of thymocytes and the development of the immune system. Interestingly, studies in zebrafish (Danio rerio) embryos have shown that TECs transform from a rounded shape to one with long projections after engaging with thymocytes, highlighting the dynamic nature of their shape. Despite the importance of these protrusions, previous computational models of TECs have often assumed that they have a fixed morphology, overlooking their dynamic nature. This study addresses this shortcoming by developing a cutting-edge, particle-based dynamic model using Tissue Forge software. The model I developed simulates the formation and retraction of TEC...Show moreMany types of cells in the body exhibit intricate shapes, often characterized by elongated projections that are essential for their function. Nerve cells are a prime example, but even immune cells such as thymic epithelial cells (TECs) in the thymus rely on these dynamic structures. TECs are large cells that play a crucial role in the maturation of thymocytes and the development of the immune system. Interestingly, studies in zebrafish (Danio rerio) embryos have shown that TECs transform from a rounded shape to one with long projections after engaging with thymocytes, highlighting the dynamic nature of their shape. Despite the importance of these protrusions, previous computational models of TECs have often assumed that they have a fixed morphology, overlooking their dynamic nature. This study addresses this shortcoming by developing a cutting-edge, particle-based dynamic model using Tissue Forge software. The model I developed simulates the formation and retraction of TEC protrusions, incorporating structural constraints and cell division dynamics. In the future, this model can be expanded to include how the morphology of TECs adapts in response to interactions with thymocytes and external forces. This model provides a dynamic framework for understanding TEC behavior, enabling future studies of TEC-thymocyte interactions and the role of TEC morphology in the development of the immune system.Show less

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Computer Modeling of Thymic Epithelial Cell Morphology